{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:20:06Z","timestamp":1790140806773,"version":"4.0.1"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["#82070381"],"award-info":[{"award-number":["#82070381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the project of Shanghai Science and Technology Commission","award":["#20ZR1431100"],"award-info":[{"award-number":["#20ZR1431100"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"crossref","award":["(202240149)"],"award-info":[{"award-number":["(202240149)"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["#82270356"],"award-info":[{"award-number":["#82270356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["#81670293"],"award-info":[{"award-number":["#81670293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the project of Shanghai Science and Technology Commission","award":["#23ZR1437200"],"award-info":[{"award-number":["#23ZR1437200"]}]},{"name":"Clinical Research Program","award":["(JYLJ202209)"],"award-info":[{"award-number":["(JYLJ202209)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiovascular adverse events represent critical complications of antineoplastic therapy with profound implications for cancer survivorship and treatment outcomes. Despite the clinical significance, comprehensive pharmacovigilance data characterizing distinctive cardiotoxicity profiles across modern cancer therapeutics remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This investigation systematically analyzes cardiotoxicity patterns associated with antineoplastic agents using the FDA Adverse Event Reporting System (FAERS) database to inform evidence-based cardiovascular monitoring strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective pharmacovigilance study utilizing disproportionality analysis and time-to-onset evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a comprehensive analysis of FAERS data spanning 2004\u20132024, employing validated disproportionality metrics including reporting odds ratio (ROR) and proportional reporting ratio (PRR) to detect significant drug-event associations. Advanced time-to-onset analysis revealed temporal patterns of cardiotoxicity development across therapeutic classes. Statistical significance was defined as ROR &gt;1 with 95% confidence intervals excluding 1.0, and PRR &gt;2 with chi-square &gt;4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Analysis of 18,289,374 reports identified 51,402 cases of antineoplastic-related cardiovascular toxicity, demonstrating distinct class-specific patterns. Anthracyclines exhibited profound associations with structural cardiac damage (doxorubicin-cardiomyopathy: ROR\u2009=\u200920.64, 95% CI: 19.87\u201321.45). Immune checkpoint inhibitors demonstrated unprecedented immune-mediated cardiac inflammation (pembrolizumab-myocarditis: ROR\u2009=\u2009245.36, 95% CI: 218.42\u2013275.88). Fluoropyrimidines showed distinctive vasospastic effects (5-fluorouracil-Prinzmetal angina: ROR\u2009=\u200918.27, 95% CI: 14.72\u201322.69). Critical temporal patterns emerged: fluoropyrimidines caused early-onset cardiotoxicity (median: 11\u2009days, IQR: 4\u201328), anthracyclines showed intermediate onset (doxorubicin median: 64\u2009days, IQR: 21\u2013156; epirubicin median: 72\u2009days, IQR: 28\u2013168), while mitoxantrone demonstrated delayed effects (median: 457\u2009days, IQR: 182\u2013891). Cardiogenic shock emerged as the most lethal manifestation with a 43.08% mortality rate (95% CI: 40.12\u201346.14).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This landmark pharmacovigilance study reveals previously uncharacterized temporal and mechanistic patterns of antineoplastic cardiotoxicity, providing an essential evidence-based framework for cardiovascular monitoring strategies. The findings highlight critical intervention windows: immediate monitoring for fluoropyrimidines, intermediate surveillance for anthracyclines (2\u20136\u2009months), and extended follow-up for agents like mitoxantrone (&gt;12\u2009months). These insights support the development of risk-stratified cardio-oncology protocols tailored to specific therapeutic classes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986251401122","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:46:40Z","timestamp":1765522000000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiotoxicity associated with antineoplastic agents: a pharmacovigilance study based on FDA adverse event reporting system"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3737-7981","authenticated-orcid":false,"given":"Xiaohan","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Northwest Hospital, the Second Hospital Affiliated to Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyin","family":"Rong","sequence":"additional","affiliation":[{"name":"Northwest Hospital, the Second Hospital Affiliated to Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahan","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-7304","authenticated-orcid":false,"given":"Jun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00514-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071674"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303633"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21341"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0348-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.09.041"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(93)90036-Q"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4795"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1406247"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00816"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30457-1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac456"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23138"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024166"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.021"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14686"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102259"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna9040039"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07404-0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae135"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac036"},{"key":"e_1_3_4_25_2","first-page":"242","article-title":"Doxorubicin-induced cardiotoxicity: a comprehensive update","volume":"12","author":"Bhutani V","year":"2025","unstructured":"Bhutani V, Varzideh F, Wilson S, et al. Doxorubicin-induced cardiotoxicity: a comprehensive update. J Cardiovasc Dev Dis 2025; 12: 242.","journal-title":"J Cardiovasc Dev Dis"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103129"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.24.0062"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34848"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.5114\/biolsport.2024.133661"},{"key":"e_1_3_4_30_2","unstructured":"S.1353\u2014Advancing American AI Act. Senate\u2014Homeland Security and Governmental Affairs Senate\u201412\/19\/2022 Placed on Senate Legislative Calendar under General Orders. Calendar No. 669; 04\/22\/2021."}],"container-title":["Therapeutic Advances in Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986251401122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20420986251401122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20420986251401122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:41:12Z","timestamp":1777592472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20420986251401122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"alternative-id":["10.1177\/20420986251401122"],"URL":"https:\/\/doi.org\/10.1177\/20420986251401122","relation":{},"ISSN":["2042-0986","2042-0994"],"issn-type":[{"value":"2042-0986","type":"print"},{"value":"2042-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"article-number":"20420986251401122"}}