{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:16:00Z","timestamp":1787584560531,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Drug Safety"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Maintaining optimal potassium levels is critical in neonates. Piperacillin\/tazobactam (TZP) is associated with hypokalemia in adults, but neonatal data are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate the incidence, severity, and determinants of TZP-associated hypokalemia (TAH) in neonates and develop a predictive model for early detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Neonates treated with TZP between January 2019 and December 2024 at Xiamen Women and Children\u2019s Hospital were included. Demographic, laboratory, and medication data were extracted. Naranjo probability scores assessed TAH causality. Multivariate logistic regression identified predictors, and a nomogram predicted TAH occurrence. Nomogram performance was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 1027 neonates initially screened, 358 met the inclusion criteria and were ultimately included in the analysis. The incidence of TAH in this cohort was 20.4% (73\/358). Independent predictors included higher baseline serum creatinine (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.012, OR 1.02, 95% CI 1.00\u20131.03), dopamine use (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002, OR 3.37, 95% CI 1.54\u20137.36), and lower serum calcium (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.049, OR 0.31, 95% CI 0.10\u20130.99) was a protective factor. The nomogram showed good predictive accuracy (AUC\u2009=\u20090.771) and net benefit. High-risk neonates had a higher hypokalemia incidence (log-rank test\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher baseline serum creatinine, dopamine use, and lower serum calcium are independent predictors of neonatal TAH. The nomogram offers a user-friendly tool for TAH prediction, facilitating early detection and management in clinical practice. This study supports early detection, diagnosis, and intervention for neonatal TAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20420986261434697","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:37:17Z","timestamp":1775565437000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence, risk factors, and prediction model of piperacillin\/tazobactam-associated hypokalemia in neonates"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1967-749X","authenticated-orcid":false,"given":"Jun","family":"Wan","sequence":"first","affiliation":[{"name":"Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiteng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-8882","authenticated-orcid":false,"given":"Wei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, 10# Zhenhai Road, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.1.205"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3635-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390707"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0109"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.62.725.187"},{"issue":"48","key":"e_1_3_4_7_2","first-page":"3921","article-title":"[Serum electrolytes and drug therapy of patients admitted to a geriatric department]","volume":"155","author":"S\u00f8rensen IJ","year":"1993","unstructured":"S\u00f8rensen IJ, Matzen LE. 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