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Parametric statistics may not be useful in studying this issue because methadone-associated TdP is a very rare event and, hence, \u201can extreme outlier\u201d consistent with scalable randomness. We may have to rely upon narrative medicine in the form of case reports with all its limitations and hazards to provide our best understanding. We report risk factors for methadone-associated QTc interval prolongation and TdP based on review of published case reports. We believe both drug manufacturers and the FDA would better serve our patients and inform clinicians if they more readily reported drug-induced outliers such as methadone-associated TdP using a case report format.<\/jats:p>","DOI":"10.1177\/2045125312469982","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T20:59:42Z","timestamp":1358801982000},"page":"219-232","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Methadone, QTc interval prolongation and\n                    <i>torsade de pointes<\/i>\n                    : Case reports offer the best understanding of this problem"],"prefix":"10.1177","volume":"3","author":[{"given":"W. 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