{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:16:46Z","timestamp":1780805806962,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["R$ 500,000.00"],"award-info":[{"award-number":["R$ 500,000.00"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"hospital de cl\u00ednicas de porto alegre","doi-asserted-by":"publisher","award":["R$ 8,000.00"],"award-info":[{"award-number":["R$ 8,000.00"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["R$ 300,000.00"],"award-info":[{"award-number":["R$ 300,000.00"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Council for Science Technology and Innovation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To date, no biomarker has been able to predict antidepressant response at an early blockade of norepinephrine or serotonin uptake. The transient nocturnal increase in plasma melatonin levels is upregulated by blocking these uptakes. The aim of this study was to test whether fluoxetine increase in urinary 6-sulfatoxymelatonin (aMT6s) is an indicator of serotonin uptake blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 20 women (35\u201345 years of age) recruited from the community had a diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-IV. Depressive symptoms were evaluated by the Beck Depression Inventory (BDI). Participants were instructed to take 20 mg of fluoxetine every morning. Every 4 weeks, the dose could be increased by 20 mg until symptom remission. The concentration of aMT6s was evaluated in overnight urine samples collected 1 day before and 1 day after the first fluoxetine dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>An increase in aMT6s correlated to a decrease in BDI score evaluated on day 45 (\u03c1\u2009=\u2009\u22120.67, p = 0.024) was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Nocturnal increase in urinary aMT6s after the first day of medication use links the early mechanism of action of fluoxetine to its clinical output 45 days later. Thus, the relationship between urinary aMT6s excretion 1 day before\/1 day after is a biomarker for predicting clinical output earlier, reducing illness burden and health care costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2045125319881927","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T06:06:43Z","timestamp":1577426803000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["6-Sulfatoxymelatonin predicts treatment response to fluoxetine in major depressive disorder"],"prefix":"10.1177","volume":"9","author":[{"given":"Juliana","family":"Jury Freitas","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nic\u00f3li","family":"Bertuol Xavier","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-3144","authenticated-orcid":false,"given":"Andr\u00e9","family":"Comiran Tonon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do HCPA\/UFRGS, Ramiro Barcelos, 2350, Centro de Pesquisa Cl\u00ednica, sala 21617, Porto Alegre, Rio Grande do Sul, CEP 90035-003, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Carissimi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Timm Pizutti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Augusto","family":"Vieira Ilgenfritz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Pekelmann Markus","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronofarmacologia, Departamento de Fisiologia, Instituto de Bioci\u00eancia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Departamento de Psiquiatria e Medicina Legal da Faculdade de Medicina, UFRGS, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Paz Hidalgo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cronobiologia e Sono do Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Psiquiatria e Ci\u00eancias do Comportamento, UFRGS, Porto Alegre, 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