{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:47Z","timestamp":1790659727888,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Stopping antidepressants is often difficult due to withdrawal. Taperingstrips were developed to facilitate antidepressant discontinuation according to the recently described Horowitz-Taylor method, allowing for personalised titration of discontinuation to the intensity of withdrawal. A taperingstrip consists of antidepressant or other medication, packaged in a 28-day roll of small daily pouches, each with the same or slightly lower dose than the one before it. We previously reported that the short-term success rate of antidepressant taperingstrips was 71%. Here, we examine longer-term outcome after 1\u20135\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients whose doctor had ordered taperingstrips between January 2015 and December 2019 were sent a questionnaire for participation in anonymised research in January 2020. Of 1012, 483 participated, of whom 408 (85%) had attempted antidepressant tapering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 408 patients included, 192 (47%) had used strips for tapering venlafaxine, 142 (35%) for paroxetine and 74 (18%) for other antidepressants. Median length of antidepressant use was 4\u2009years, and most (61%) had tried to come off without taperingstrips at least once. After 1\u20135\u2009years, 270 patients (66%) remained off antidepressants after tapering their antidepressant, 6 (2%) had successfully reduced their medication, 87 (21%) had restarted due to (self-reported) relapse, 35 had restarted for another indication (9%), and 10 (3%) reported another outcome. People with more severe experience of withdrawal prior to tapering, and people who had been on antidepressants for a shorter period of time, were more likely to remain off medication after 1\u20135\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The previously reported 71% short-term success rate of taperingstrips in the most severely affected group, was matched by a 68% rate after 1\u20135\u2009years. The evidence-based approach of personal tapering to counter withdrawal, as used for drugs causing withdrawal, for example, benzodiazepines, may represent a simple solution for an important antidepressant-related public health problem, without extra costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2045125320954609","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T07:29:45Z","timestamp":1599031785000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Outcome of antidepressant drug discontinuation with taperingstrips after 1\u20135 years"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-1469","authenticated-orcid":false,"given":"Peter C.","family":"Groot","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University Medical Centre Utrecht, Postbus 85500, Utrecht, 3508 GA, The Netherlands"},{"name":"Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"Department of Psychosis Studies, King\u2019s College London, King\u2019s Health Partners, Institute of Psychiatry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-1586","authenticated-orcid":false,"given":"Jim","family":"van Os","sequence":"additional","affiliation":[{"name":"User Research Centre Netherlands, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"bibr1-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.08.027"},{"key":"bibr2-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1159\/000491524"},{"key":"bibr3-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320921694"},{"key":"bibr4-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30331-1"},{"key":"bibr5-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119878171"},{"key":"bibr6-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2019.106157"},{"key":"bibr7-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30032-X"},{"key":"bibr8-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320932452"},{"key":"bibr9-2045125320954609","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.17r02211"},{"key":"bibr10-2045125320954609","unstructured":"Groot PC, Consensusgroup T. [Taperingstrips for paroxetine and venlafaxine]. Tijdschr Psychiatr 2013; 55: 789\u2013794. (English version www.taperingstrip.nl\/wp-content\/uploads\/Groot_2013_Taperingstrips_paroxetine_venlafaxine.pdf)."},{"key":"bibr11-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1080\/17522439.2018.1469163"},{"key":"bibr12-2045125320954609","volume-title":"Development and Rationale of Taperingstrips. Report for Taperingstrip Preparatory Meeting Zorginstituut Nederland, 29-3-2017","author":"Groot PC.","year":"2017"},{"key":"bibr13-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30182-8"},{"key":"bibr14-2045125320954609","doi-asserted-by":"publisher","DOI":"10.2174\/1574886313666180605095130"},{"key":"bibr15-2045125320954609","volume-title":"Report of the CSM expert working group on the safety of selective serotonin reuptake inhibitor antidepressants","author":"Weller IVD","year":"2005"},{"key":"bibr16-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0351-z"},{"key":"bibr17-2045125320954609","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0910"},{"key":"bibr18-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09060880"},{"key":"bibr19-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2020.6"},{"key":"bibr20-2045125320954609","doi-asserted-by":"publisher","DOI":"10.1159\/000441458"}],"container-title":["Therapeutic Advances in Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2045125320954609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2045125320954609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2045125320954609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:52:04Z","timestamp":1777593124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2045125320954609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":20,"alternative-id":["10.1177\/2045125320954609"],"URL":"https:\/\/doi.org\/10.1177\/2045125320954609","relation":{},"ISSN":["2045-1253","2045-1261"],"issn-type":[{"value":"2045-1253","type":"print"},{"value":"2045-1261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2045125320954609"}}