{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:25:05Z","timestamp":1788341105827,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Many older adults experience a deterioration in cognitive function with aging, and this can have a negative impact on quality of life. Late-life depression has been linked to mild cognitive impairment and dementia, and treating depression with an agent that has procognitive effects could be beneficial. Vortioxetine is a novel antidepressant with a multimodal mechanism of action that works primarily via serotonin transporter inhibition, 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor agonism and 5-HT\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonism. A recent systematic review demonstrated procognitive effects of vortioxetine when indirectly compared with selective serotonin reuptake inhibitors and serotonin\u2013norepinephrine reuptake inhibitors in adults aged 18\u201365 years with major depressive disorder. While this systematic review demonstrated promising procognitive effects from vortioxetine, the included studies did not enroll older adults, who are at the highest risk of cognitive impairment. Therefore, our systematic review sought to investigate the effects of vortioxetine on cognitive functioning in patients over the age of 65 years. Three studies met the prespecified search criteria and were evaluated. Overall, these preliminary data suggest that vortioxetine has promising effects in improving cognition in older adults with depressive symptoms and may have a place in therapy in older adults with depression and\/or cognitive impairment, including Alzheimer\u2019s disease. Additional long-term studies that include more diverse populations with comorbidities and direct comparisons with other antidepressants are needed to fully understand the potential cognitive benefits in older adults.\n                  <\/jats:p>","DOI":"10.1177\/20451253211026796","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T03:16:20Z","timestamp":1626923780000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Cognitive effects of vortioxetine in older adults: a systematic review"],"prefix":"10.1177","volume":"11","author":[{"given":"Makenna M.","family":"Bishop","sequence":"first","affiliation":[{"name":"University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-1756","authenticated-orcid":false,"given":"Danielle R.","family":"Fixen","sequence":"additional","affiliation":[{"name":"University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA"},{"name":"University of Colorado Health, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny A.","family":"Linnebur","sequence":"additional","affiliation":[{"name":"University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA"},{"name":"University of Colorado Health, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-6734","authenticated-orcid":false,"given":"Scott M.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, 12850 E. Montview Boulevard; Mail Stop C238, Aurora, CO 80045, USA"},{"name":"University of Colorado Health, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"bibr1-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.032408.153621"},{"key":"bibr2-20451253211026796","first-page":"35","volume":"15","author":"Aziz R","year":"2017","journal-title":"Focus (Am Psychiatr Publ)"},{"key":"bibr3-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0514-6"},{"key":"bibr4-20451253211026796","first-page":"201","volume":"25","author":"Hanninen T","year":"1996","journal-title":"et al."},{"key":"bibr5-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.030"},{"key":"bibr6-20451253211026796","first-page":"14968","volume":"108","author":"Cirrito JR","year":"2011","journal-title":"et al."},{"key":"bibr7-20451253211026796","first-page":"232","volume":"175","author":"Bartels C","year":"2018","journal-title":"et al."},{"key":"bibr8-20451253211026796","first-page":"900","volume":"164","author":"Raskin J","year":"2007","journal-title":"et al."},{"key":"bibr9-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070889"},{"key":"bibr10-20451253211026796","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19r13200"},{"key":"bibr11-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.07.001"},{"key":"bibr12-20451253211026796","first-page":"36","volume":"40","author":"D\u2019Agostino A","year":"2015","journal-title":"P T"},{"key":"bibr13-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3283542457"},{"key":"bibr14-20451253211026796","first-page":"192","volume":"6","author":"Cumbo E","year":"2019","journal-title":"J Prev Alzheimers Dis"},{"key":"bibr15-20451253211026796","first-page":"548","volume-title":"Am J Psychiatry","volume":"177","author":"Lenze EJ","year":"2020"},{"key":"bibr16-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"bibr17-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqv043"},{"key":"bibr18-20451253211026796","volume":"2015","author":"Arevalo-Rodriguez I","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr19-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000941"},{"key":"bibr20-20451253211026796","first-page":"688","volume":"45","author":"Rosano C","year":"2016","journal-title":"et al."},{"key":"bibr21-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199311)49:6<883::AID-JCLP2270490616>3.0.CO;2-6"},{"key":"bibr22-20451253211026796","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"bibr23-20451253211026796","first-page":"588","volume":"20","author":"Heaton RK","year":"2014","journal-title":"et al."},{"key":"bibr24-20451253211026796","unstructured":"H. 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