{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:35:56Z","timestamp":1783121756190,"version":"3.54.6"},"reference-count":56,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Clinical Trial and Research Center at National Taiwan University Hospital","award":["NCTRC200724"],"award-info":[{"award-number":["NCTRC200724"]}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC 96-2628-B-002-066-MY2"],"award-info":[{"award-number":["NSC 96-2628-B-002-066-MY2"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC98-2314-B-002-125-MY3"],"award-info":[{"award-number":["NSC98-2314-B-002-125-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aripiprazole has been reported to worsen psychotic symptoms when switching from other antipsychotics, possibly due to dopamine supersensitivity psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to explore the predictors and possible underlying mechanisms of aripiprazole-related psychotic exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted an 8-week, open-label, randomized controlled study from October 2007 to September 2009, assigning patients with a primary diagnosis of schizophrenia or schizoaffective disorder to switch from other antipsychotics to aripiprazole with 2-week dual administration, and then to taper off the original agents in fast (n\u2009=\u200938, within 1 week) or slow (n\u2009=\u200941, within 4\u2009weeks) strategies. Positive and Negative Syndrome Scale (PANSS) was examined at day 0, 7, 14, 28, 56. Aripiprazole-related exacerbation (ARE) was defined positive as a 2-point increase in delusion\/hallucination dimension score within 28\u2009days compared with baseline. Baseline demographic, clinical and intervention-related variables were compared between the ARE+ and ARE- groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 79 randomized patients, 21 fulfilled the criteria of ARE+ , and 46 were classified as ARE-. Fourteen patients in the ARE+ group had worsening psychotic symptoms in the first and second weeks. Compared with the ARE- group, the ARE+ group had a higher baseline chlorpromazine equivalent dose (405.8\u2009\u00b1\u2009225.8\u2009mg vs 268.1\u2009\u00b1\u2009165.4\u2009mg, p\u2009=\u20090.007) and was associated with prescription of first-generation antipsychotics ( p\u2009=\u20090.038).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A higher dose of original antipsychotics and prescription of first-generation antipsychotics may be associated with a higher risk of ARE. The underlying mechanism might be covert dopamine supersensitivity psychosis. These findings may help to identify high-risk patients and guide appropriate treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, identifier: NCT00545467<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253211064396","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:13:10Z","timestamp":1643346790000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying dopamine supersensitivity through a randomized controlled study of switching to aripiprazole from other antipsychotic agents in patients with schizophrenia"],"prefix":"10.1177","volume":"12","author":[{"given":"Chia-Hao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital Yunlin Branch, Douliu City"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8479-5418","authenticated-orcid":false,"given":"Hung-Yu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of General Psychiatry, Taoyuan Psychiatric Center, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming H.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Gwo","family":"Hwu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hua","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-9484","authenticated-orcid":false,"given":"Tzung-Jeng","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei 10002"},{"name":"Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, 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