{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:53:13Z","timestamp":1789523593917,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Therapeutic drug monitoring (TDM) is useful to assess clozapine adherence and optimize treatment. However, analysis of venous blood levels by liquid chromatography tandem mass spectrometry (LC-MS\/MS) is often logistically complicated and process time is prolonged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the feasibility and reliability of a new point-of-care device, (MyCare\u2122 Insite), using capillary blood for clozapine therapeutic monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Matched venous and capillary blood samples were collected from patients treated with clozapine on a stable dose. Samples were analyzed by LC-MS\/MS and MyCare Insite Clozapine Test. Clozapine plasma levels were compared between methods using linear regression model. Both patients and treatment team completed questionnaires about the feasibility of blood sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the total sample (44 patients, 61% males, mean age 43\u2009\u00b1\u200912 years), mean daily clozapine dose was 293\u2009\u00b1\u2009134 mg\/day. Linear regression model demonstrated high correlation with R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.83 ( p\u2009&lt;\u20090.0001) and mean difference of 26\u2009\u00b1\u2009162 ng\/ml. More than 60% of the patients found the clozapine TDM to be important. Most of the participants (58%) favored the capillary sampling and 11% claimed that testing method would affect their adherence to TDM. Moreover, a larger portion (72%) strongly preferred to be tested at the office rather than at the lab.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The point-of-care device offers an accessible and satisfactory measurement of clozapine blood levels. Both patients and healthcare providers reported preference for capillary sampling as well as for the in-office TDM procedure. The immediate results provided by the device can facilitate rapid and informed clinical decisions and therefore improve clozapine treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253221094435","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T04:57:41Z","timestamp":1655182661000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clozapine blood level assessment using a point-of-care device: feasibility and reliability"],"prefix":"10.1177","volume":"12","author":[{"given":"Shiri","family":"Kamhi-Nesher","sequence":"first","affiliation":[{"name":"Geha Mental Health Center, 1 Helsinki street, P.O. Box 102, Petah-Tikva 49100, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-9350","authenticated-orcid":false,"given":"Sharon","family":"Taub","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, 1 Helsinki street, P.O. Box 102, Petah-Tikva 49100, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikma","family":"Halimi","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Frenkel","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmud","family":"Azam","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Bormant","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Isakov","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikla","family":"Radzinsky","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[{"name":"Geha Mental Health Center, Petah-Tikva, 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