{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:09:56Z","timestamp":1791475796279,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-adherence to antipsychotics in schizophrenia is associated with an increased risk of psychotic relapse and hospitalization, a risk that is reduced with the use of long-acting injectable (LAI) antipsychotics. Randomized clinical trials (RCTs) have demonstrated the efficacy of paliperidone palmitate 3-monthly (PP3M) for psychotic relapse prevention in schizophrenia, but it remains poorly documented among individuals treated in real-life settings who can benefit the most out of LAIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the effectiveness of PP3M in relapse prevention among patients with schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a multicentre retrospective study conducted in four outpatients\u2019 clinics across Canada. All consecutive patients with a main diagnosis of schizophrenia who initiated PP3M between June 2016 and March 2020 were included. The primary outcome was psychotic relapse, defined using broad and clinically relevant criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 178 consecutive patients who were switched to PP3M, the 12-month relapse rate was 18.5% and the relapse-free survival probability was 0.788 (95% confidence interval [CI]\u2004=\u20040.725\u20130.856). Comorbid diagnoses of personality disorders and substance use disorders were associated with hazard rates (HRs) of 3.6 (95% CI\u2004=\u20041.8\u20137.3, p\u2009&lt;\u20090.001) and 3.1 (95% CI\u2004=\u20041.6\u20136.2), respectively. Increased psychopathology severity was associated with an increased likelihood of relapse, while having a job or being in school was protective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings reinforce the necessity of conducting research in patients with comorbid psychiatric disorders who are typically underrepresented in RCTs, yet overrepresented in real-life settings, in order to better inform and guide clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253221136021","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T03:14:56Z","timestamp":1668482096000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Real-life effectiveness of transitioning from paliperidone palmitate 1-monthly to paliperidone palmitate 3-monthly long-acting injectable formulation"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-853X","authenticated-orcid":false,"given":"Olivier","family":"Corbeil","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, 1050 Av. de la M\u00e9decine, Quebec City, QC G1V 0A6, Canada"},{"name":"Quebec Mental Health University Institute, Quebec City, QC, Canada"},{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Essiambre","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"},{"name":"School of Psychology, Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-1799","authenticated-orcid":false,"given":"Laurent","family":"B\u00e9chard","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, Quebec City, QC, Canada"},{"name":"Quebec Mental Health University Institute, Quebec City, QC, Canada"},{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey-Anne","family":"Roy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Huot-Lavoie","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Brodeur","sequence":"additional","affiliation":[{"name":"Quebec Mental Health University Institute, Quebec City, QC, Canada"},{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"},{"name":"Department of Psychiatry, Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith","family":"Chandrasena","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantale","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Crocker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS, 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