{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:56:26Z","timestamp":1792637786991,"version":"4.5.0"},"reference-count":97,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>More than 2% of the general population experience suicidal ideas each year and a large number of them will attempt suicide. Evidence-based therapeutic options to manage suicidal crisis are currently limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to overview the findings on the use of ketamine and esketamine for the treatment of suicidal ideas and acts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources and methods:<\/jats:title>\n                    <jats:p>PubMed, article references, and Clinicaltrials.gov up to June 30, 2022. Meta-analyses published within the last 2\u2009years were also reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 12 randomized controlled trials with reduction of suicidal ideation as the primary objective and 14 trials as secondary objectives. Intravenous racemic ketamine was superior to control drugs (placebo or midazolam) within the first 72\u2009h, in spite of large placebo effects. Adverse events were minor and transient. In contrast, intranasal esketamine did not differ from placebo in large-scale studies. Limitations, clinical considerations, and opportunities for future research include the following points: large placebo effects when studying suicidal ideation reduction; small concerns about blinding quality due to dissociative effects; no studies on the risk\/prevention of suicidal acts and mortality; lack of studies beyond affective disorders; no studies in adolescents and older people; lack of knowledge of long-term side effects, notably liability for abuse; no robust predictive markers; limited understanding of the mechanisms of ketamine on suicidal ideas; need for improved assessment of suicidal ideation in clinical trials; need for studies in outpatient settings, emergency room, and liaison consultation; need for research on ketamine administration; limited knowledge on the positive and negative effects of concomitant treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Overall, there is compelling evidence for a favorable short-term benefit-risk balance with intravenous racemic ketamine but not intranasal esketamine. The place of ketamine will have to be defined within a multimodal care strategy for suicidal patients. Caution remains necessary for clinical use, and pharmacovigilance will be essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253231151327","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T07:14:39Z","timestamp":1675754079000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":61,"title":["Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-4503","authenticated-orcid":false,"given":"Fabrice","family":"Jollant","sequence":"first","affiliation":[{"name":"Service de Psychiatrie, CHU Bic\u00eatre, APHP, 78 Rue du G\u00e9n\u00e9ral Leclerc, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"Faculty of Medicine, University Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"MOODS Team, Inserm 1018, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), Le Kremlin-Bic\u00eatre, France"},{"name":"Department of Psychiatry, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Department of Psychiatry & McGill Group for Suicide Studies, McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Colle","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"Department of Psychiatry, CHU Bic\u00eatre, APHP, Le Kremlin-Bic\u00eatre, France"},{"name":"MOODS Team, Inserm 1018, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Mai Loan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University Paris-Saclay, Orsay, France"},{"name":"MOODS Team, Inserm 1018, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Corruble","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"Department of Psychiatry, CHU Bic\u00eatre, APHP, Le Kremlin-Bic\u00eatre, France"},{"name":"MOODS Team, Inserm 1018, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain M.","family":"Gardier","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University Paris-Saclay, Orsay, France"},{"name":"MOODS Team, Inserm 1018, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP), Le Kremlin-Bic\u00eatre, 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