{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:12Z","timestamp":1791304272173,"version":"4.3.1"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In the last few years, ketamine is becoming increasingly common in the treatment of mental health conditions, but there is a lack of safety data informing intramuscular and sublingual dosing in a community-focused group psychotherapy setting. The Roots To Thrive ketamine-assisted therapy (RTT-KaT) program is a unique 12-week RTT-KaT program with 12 community of practice (a form of group therapy) sessions and three ketamine medicine sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study reports on adverse effects of intramuscular and sublingual ketamine dosing in a community group psychotherapy setting among 128 participants across four cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A chart review of the RTT-KaT Program was performed retrospectively on four cohorts ( n\u2009=\u2009128) that participated in 448 sessions running between September 2020 and December 2021. Baseline characteristics and adverse events were captured including medication administration before, during, and after RTT-KaT sessions. Analyses by session and by individual were conducted. Chi-square test with Yates\u2019 continuity correction was used to assess side effects in subgroups from ketamine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>RTT-KaT was well tolerated with none of the 128 participants dropping out of the program. Primarily, of the 448 sessions, 49.16% had elevated blood pressures post-KaT session by session. In terms of other adverse effects, 12.05% of participant-sessions experienced nausea, 2.52% had an episode of vomiting, 3.35% had a headache, and seven participant-sessions experienced dizziness. Analysis by individual revealed congruent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest good safety and tolerability for RTT-KaT among individuals seeking treatment for mental health issues. The majority of participants did not experience adverse reactions and the adverse events that were recorded involved transient symptoms that were resolved with rest and\/or medications. The group therapy model described provides a comprehensive approach and presents a promising model for operating a KaT program in a community setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253231171512","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T06:50:48Z","timestamp":1684997448000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: a retrospective chart review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-008X","authenticated-orcid":false,"given":"Vivian W.L.","family":"Tsang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-3162","authenticated-orcid":false,"given":"Brendan","family":"Tao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Dames","sequence":"additional","affiliation":[{"name":"Health Sciences and Human Services, Vancouver Island University, Nanaimo, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zach","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of British Columbia, Kelowna, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Kryskow","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"bibr1-20451253231171512","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00612"},{"key":"bibr2-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.07.004"},{"key":"bibr3-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1300\/J020V09N01_09"},{"key":"bibr4-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.1997.10400185"},{"key":"bibr5-20451253231171512","volume":"8","author":"Walsh Z","year":"2022","journal-title":"BJPsych Open"},{"key":"bibr6-20451253231171512","volume-title":"Paper presented at the Eleventh Annual Meeting of the Association for Humanistic Psychology","author":"Yensen R"},{"key":"bibr7-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2019.1587556"},{"key":"bibr8-20451253231171512","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.803279"},{"key":"bibr9-20451253231171512","unstructured":"KETALAR (ketamine hydrochloride) injection, https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/016812s043lbl.pdf (accessed 24 July 2022)."},{"key":"bibr10-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.038"},{"key":"bibr11-20451253231171512","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.648691"},{"key":"bibr12-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20010018"},{"key":"bibr13-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz039"},{"key":"bibr14-20451253231171512","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19m13191"},{"key":"bibr15-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.007"},{"key":"bibr16-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1002\/da.22875"},{"key":"bibr17-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03538-y"},{"key":"bibr18-20451253231171512","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.008"},{"key":"bibr19-20451253231171512","unstructured":"Highlights of prescribing information (SPRAVATO), https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/211243s004lbl.pdf (accessed 9 August 2022)."},{"key":"bibr20-20451253231171512","unstructured":"Kim J, Chen Q. 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