{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:44:59Z","timestamp":1793378699795,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["No.Z211100003521016"],"award-info":[{"award-number":["No.Z211100003521016"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Post-traumatic stress disorder (PTSD) is a prevalent mental illness with a high disability rate. The neurobiological abnormalities in PTSD suggest that drug therapy may have certain therapeutic effects. According to the recommendations of clinical guidelines for PTSD, the current clinical preference is for selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs). Nevertheless, the efficacy of other types of drugs remains uncertain, which impacts the selection of personalized treatment for patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this meta-analysis was to assess the efficacy and acceptability of drugs with different pharmacological mechanisms in alleviating PTSD symptoms by comparing the response rates and dropout rates of different drug treatment groups in randomized clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched and analyzed 52 reports that described the efficacy and acceptability of medication for PTSD. Among these, 49 trials used the dropout rate as an acceptability indicator, and 52 trials used the response rate as an efficacy indicator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the 49 trials with the dropout rate as the indicator, the dropout rate was 29% (95% confidence interval, 0.26\u20130.33;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093870). In the 52 trials with the response rate as the indicator, the response rate was 39% (95% confidence interval, 0.33\u20130.45;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093808). After drug treatment, the core symptoms of PTSD were significantly improved. This meta-analysis indicated that there was no significant difference between antidepressants and antipsychotics in improving clinical symptoms and acceptability. However, the antipsychotics may have a slight advantage in efficacy, albeit with a higher dropout rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Drug treatment is an effective rehabilitation method for PTSD patients, and individualized drug management should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>This systematic evaluation scheme has been registered with PROSPERO (protocol ID: CRD42023462662).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253251342628","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:29:52Z","timestamp":1749875392000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3852-798X","authenticated-orcid":false,"given":"Yanyan","family":"Jia","sequence":"first","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3368-6717","authenticated-orcid":false,"given":"Zifeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology of Hainan Hospital, Chinese PLA General Hospital, Sanya, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5943-6271","authenticated-orcid":false,"given":"Fude","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-2768","authenticated-orcid":false,"given":"Jiabao","family":"Chai","sequence":"additional","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-2744","authenticated-orcid":false,"given":"Haiting","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-4414","authenticated-orcid":false,"given":"Jingming","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8976-0855","authenticated-orcid":false,"given":"Weiye","family":"Liang","sequence":"additional","affiliation":[{"name":"Beijing Huilongguan Hospital, Peking University, No. 7 Courtyard, Nandian North Road, Changping District, Beijing 100096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-6238","authenticated-orcid":false,"given":"Lili","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Mental Health, Naval Medical University, 800 Xiangyin Road, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200620070-00003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jts.21814"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000708"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_3_4_7_2","volume-title":"The Veterans Health Administration's Treatment of PTSD and Traumatic Brain Injury Among Recent Combat Veterans","author":"Congress of The United States Congressional Budget Office","year":"2012","unstructured":"Congress of The United States Congressional Budget Office. 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