{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:34:49Z","timestamp":1792928089802,"version":"4.5.0"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psychiatric patients have a high risk of obesity, frequently due to psychotropic medication-induced weight gain. However, real-world comparative data on antiobesity medications (AOMs) in this population remain rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare short-term weight-loss efficacy, adverse events (AEs), and early discontinuation (ED) among psychiatric outpatients taking liraglutide (LIRA), naltrexone\/bupropion, phentermine-topiramate (PT), or metformin (MET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a 12-week retrospective chart review of 117 psychiatric outpatients with International Classification of Diseases, 10th Revision, F01\u2013F99 diagnoses. Percent weight change over time was analyzed using linear mixed-effects models. AEs and ED were compared across treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with MET, LIRA was associated with a greater percent weight reduction (estimate \u22123.45%, 95% confidence interval (CI) \u22125.35 to \u22121.55,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a significant treatment-by-time interaction at 12\u2009weeks (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.019). Female sex and full-time employment were associated with attenuated weight loss, and the number of concomitant psychotropic medications with moderate weight-gain risk showed a trend toward greater weight reduction (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.066). No significant differences were observed in AE incidence across AOMs. ED rates differed by drug type (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.017), being lowest in the MET group (39.1%) and highest in the PT group (72.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this real-world psychiatric cohort, LIRA was associated with greater short-term weight loss than MET without an increased observed frequency of AEs. ED rates varied across AOMs. These findings should be interpreted cautiously, given the observational design and short follow-up period, and require confirmation in larger, long-term studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253261419609","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:16:11Z","timestamp":1771485371000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative efficacy and safety of liraglutide versus metformin, naltrexone\/bupropion, and phentermine-topiramate in psychiatric patients"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-9504","authenticated-orcid":false,"given":"Won-Seok","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Korea University Guro Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-5743","authenticated-orcid":false,"given":"Min-Kyu","family":"Song","sequence":"additional","affiliation":[{"name":"St. Mary\u2019s Gong-Gam Mental Health Clinic, Siheung, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2713-1588","authenticated-orcid":false,"given":"Mansuk","family":"Seo","sequence":"additional","affiliation":[{"name":"Mapo St. Mary\u2019s Psychiatric Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-838X","authenticated-orcid":false,"given":"Young Sup","family":"Woo","sequence":"additional","affiliation":[{"name":"Woo and Bahk Psychiatry Clinic, 601, 6F, 36, 63-ro, Yeongdeungpo-gu, Seoul 07345, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-2510","authenticated-orcid":false,"given":"Won-Myong","family":"Bahk","sequence":"additional","affiliation":[{"name":"Woo and Bahk Psychiatry Clinic, 601, 6F, 36, 63-ro, Yeongdeungpo-gu, Seoul 07345, Republic of KoreaDepartment of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.247"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000503835"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1523"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.7075su1c.03"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0349.2010.00721.x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230922"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/foc.3.4.511"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2020.49799"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02447-w"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10432"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.24.1237"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116645254"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000502293"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2017.04.003"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbae205"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2021-300291"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1049-5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23032"},{"key":"e_1_3_4_20_2","article-title":"Weight loss medication phentermine-induced hypomania in bipolar depression","volume":"26","author":"Jumaili WA","year":"2024","unstructured":"Jumaili WA, Gburi NA, Jain S. 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