{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:30:03Z","timestamp":1777879803436,"version":"3.51.4"},"reference-count":89,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Czech Health Research Council","doi-asserted-by":"crossref","award":["NV18-04-00260"],"award-info":[{"award-number":["NV18-04-00260"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009553","name":"Czech Health Research Council","doi-asserted-by":"crossref","award":["NW24-04-00413"],"award-info":[{"award-number":["NW24-04-00413"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"crossref"}]},{"name":"OP JAK BRADY","award":["CZ.02.01.01\/00\/22_008\/0004643"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004643"]}]},{"name":"ERDF\/ESF project PharmaBrain","award":["CZ.02.1.01\/0.0\/0.0\/16_025\/0007444"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_025\/0007444"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Psychopharmacology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ketamine is a rapid-acting antidepressant with robust evidence, but unclear predictors of therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Based on previous knowledge, hemodynamic parameters and acute altered state of consciousness have been hypothesized as potential correlates of subsequent antidepressant outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A post hoc analysis was performed using the data from an open-label study, in which 39 patients with depression received a single intravenous infusion of ketamine (0.54\u2009mg\/kg). Antidepressant response was defined as \u2a7e50% reduction in the Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) at day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Systolic and diastolic blood pressure (SBP and DBP), heart rate, Clinician-Administered Dissociative States Scale (CADSS) and Brief Psychiatric Rating Scale (BPRS) were assessed during the infusion, alongside plasma levels of ketamine and norketamine. Data were analyzed using mixed-effects models and correlation and regression techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Responders exhibited significantly higher SBP and DBP during ketamine infusion compared with nonresponders. The degree of dissociation or psychotomimetic symptoms during the infusion did not differ significantly between responders and nonresponders. Antipsychotic (AP) augmentation was associated with worse antidepressant outcome as well as with lower infusion-related blood pressure values. CADSS and BPRS did not differ between AP users and nonusers. None of the parameters correlated with plasma levels of ketamine or norketamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher blood pressure during ketamine administration was associated with better antidepressant outcome, supporting the hypothesis concerning sympathetic activation in treatment responders. Psychological parameters (as measured by CADSS and BPRS) were not linked to subsequent outcomes and did not resolve inconsistencies in previous studies. Concomitant antipsychotic medication attenuated ketamine\u2019s antidepressant effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>EudraCT 2018-001539-39.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20451253261419636","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:15:56Z","timestamp":1771586156000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sympathetic activation but not dissociation linked to ketamine\u2019s sustained antidepressant effect"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-3345","authenticated-orcid":false,"given":"Veronika","family":"Andrashko","sequence":"first","affiliation":[{"name":"National Institute of Mental Health, Topolova 748, Klecany 25067, Czech Republic, Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-9654","authenticated-orcid":false,"given":"Tomas","family":"Novak","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Klecany, Czech Republic"},{"name":"Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-6887","authenticated-orcid":false,"given":"Miloslav","family":"Kopecek","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Klecany, Czech Republic"},{"name":"Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-9577","authenticated-orcid":false,"given":"Anna","family":"Sulakova","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Klecany, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit","family":"Knop","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Klecany, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-7306","authenticated-orcid":false,"given":"Jiri","family":"Horacek","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Klecany, Czech Republic"},{"name":"Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.1.28"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00230-9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.856"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05825-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.04.037"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.04.039"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102127"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01732-8"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114527361"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113478283"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18070834"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.031"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.014"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991619"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3669-0"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.021"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2019.1635270"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08698"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118793104"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09049"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.050"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/3\/003"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-025-03430-3"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.12.001"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-12-4"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.01.030"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001542"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172827"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.130"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.053"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2884"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2023.109422"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa087"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.12.023"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/psych4010012"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881121998321"},{"issue":"4","key":"e_1_3_4_40_2","first-page":"287","article-title":"Relationship of ketamine\u2019s antidepressant and psychotomimetic effects in unipolar depression","volume":"34","author":"Sos P","year":"2013","unstructured":"Sos P, Klirova M, Novak T, et al. Relationship of ketamine\u2019s antidepressant and psychotomimetic effects in unipolar depression. Neuro Endocrinol Lett 2013; 34(4): 287\u2013293.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2019.11.004"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00974"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.02.017"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.10.026"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0256-5"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.03.026"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.10.009"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026769"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000960"},{"key":"e_1_3_4_50_2","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan DV","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22\u201333.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000511"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv124"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01866-8"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024465317902"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.03.021"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv037"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjment-2022-300546"},{"key":"e_1_3_4_64_2","first-page":"585","article-title":"Short-term ketamine administration in treatment-resistant depression: focus on cardiovascular safety","volume":"31","author":"Szarmach J","year":"2019","unstructured":"Szarmach J, Cuba\u0142a WJ, W\u0142odarczyk A, et al. Short-term ketamine administration in treatment-resistant depression: focus on cardiovascular safety. Psychiatr Danub 2019; 31(Suppl 3): 585\u2013590.","journal-title":"Psychiatr Danub"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(74)90377-3"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221140011"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2024.100316"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00844"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0492-x"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05121-6"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177036"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000959"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.03.029"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137095"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0028-2"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2018.09.001"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-024-02044-5"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852924002451"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200023030-00004"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1424"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-017-0543-0"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00546-X"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.201665"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0136-3"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv060"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17998"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.03.001"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.141"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(22)00317-0"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.01.165"}],"container-title":["Therapeutic Advances in Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20451253261419636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20451253261419636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20451253261419636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:53:59Z","timestamp":1777593239000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20451253261419636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":89,"alternative-id":["10.1177\/20451253261419636"],"URL":"https:\/\/doi.org\/10.1177\/20451253261419636","relation":{},"ISSN":["2045-1253","2045-1261"],"issn-type":[{"value":"2045-1253","type":"print"},{"value":"2045-1261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"article-number":"20451253261419636"}}