{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:57:19Z","timestamp":1790704639527,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Pulmonary tumor thrombotic microangiopathy (PTTM) is a disease process wherein tumor cells are thought to embolize to the pulmonary circulation causing pulmonary hypertension (PH) and death from right heart failure. Presented herein are clinical, laboratory, radiographic, and histologic features across seven cases of PTTM. Highlighted in this publication are also involvement of pulmonary venules and clinical features distinguishing PTTM from clinical mimics.<\/jats:p><jats:p>We conducted a retrospective chart review of seven cases of PTTM from hospitals in the greater Los Angeles metropolitan area.<\/jats:p><jats:p>Patients in this series exhibited: symptoms of cough and progressive dyspnea; PH and\/or heart failure on physical exam; laboratory abnormalities of anemia, thrombocytopenia, elevated LDH, and elevated D\u2010dimer; chest computed tomography (CT) showing diffuse septal thickening, mediastinal and hilar lymphadenopathy and nodules; elevated pulmonary artery pressures on transthoracic echocardiogram and\/or right heart catheterization; and presence of malignancy. Tumor emboli and fibrocellular intimal proliferation were seen in pulmonary arterioles, while two patients had pulmonary venopathy.<\/jats:p><jats:p>PTTM is a devastating disease occurring in patients with metastatic carcinoma. An early diagnosis is challenging. Understanding the clinical presentation of PTTM and distinguishing PTTM from clinical mimics may help achieve an early diagnosis and allow time for initiation of treatment.<\/jats:p>","DOI":"10.1177\/2045893217728072","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T15:36:04Z","timestamp":1502120164000},"page":"813-820","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Insights on pulmonary tumor thrombotic microangiopathy: a seven\u2010patient case series"],"prefix":"10.1002","volume":"7","author":[{"given":"Rohit","family":"Godbole","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of California Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Saggar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-7315","authenticated-orcid":false,"given":"Alexander","family":"Zider","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Betancourt","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine West Los Angeles Veterans Affairs Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA 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