{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:02:27Z","timestamp":1790524947665,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL087738\u201008"],"award-info":[{"award-number":["T32 HL087738\u201008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL125212\u201001"],"award-info":[{"award-number":["U01 HL125212\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34 HL141317"],"award-info":[{"award-number":["R34 HL141317"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13FTF16070002"],"award-info":[{"award-number":["13FTF16070002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["#13FTF16070002"],"award-info":[{"award-number":["#13FTF16070002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#1 U01 HL125212-01"],"award-info":[{"award-number":["#1 U01 HL125212-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#5 T32 HL087738-08"],"award-info":[{"award-number":["#5 T32 HL087738-08"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["Pulmonary Arterial Hypertension Scholars Award Pro"],"award-info":[{"award-number":["Pulmonary Arterial Hypertension Scholars Award Pro"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasians has rarely been reported. In this study, we examined whether racial differences exist in patients referred for right heart catheterization (RHC) and hypothesized that AA race is an independent risk factor for PH and is associated with increased adjusted mortality. We extracted data for AA and Caucasian patients who underwent RHC at Vanderbilt between 1998 and 2014. Clinical information was obtained from Vanderbilt's Synthetic Derivative, a de\u2010identified mirror of our Electronic Medical Record. A total of 4576 patients were analyzed, including 586 (13%) AAs and 3990 (87%) Caucasians. AAs were younger than Caucasians by an average of eight years, but had more prevalent heart failure, features of metabolic syndrome, and higher creatinine. AAs also had higher mean pulmonary artery pressure and pulmonary vascular resistance. After adjusting for relevant co\u2010morbidities, the AA race is associated with 41% increased risk of PH (odds ratio [OR]\u2009=\u20091.41, 95% confidence interval [CI]\u2009=\u20091.12\u20131.79). Among patients with PH, AA race is associated with 24% increased adjusted mortality (hazard ratio [HR]\u2009=\u20091.24, 95% CI\u2009=\u20091.09\u20131.45). AAs were younger but had more prevalent cardiometabolic and renal disease and worse pulmonary hemodynamics. The AA race is an independent risk factor for PH. Among patients with PH, the AA race is associated with increased adjusted mortality. Future studies should focus on delineating whether genetic or environmental factors contribute to PH risk in AAs.<\/jats:p>","DOI":"10.1177\/2045894018764273","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T13:26:43Z","timestamp":1519651603000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Racial differences in patients referred for right heart catheterization and risk of pulmonary hypertension"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-145X","authenticated-orcid":false,"given":"Bin Q.","family":"Yang","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Department of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tufik R.","family":"Assad","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Allergy Pulmonary and Critical Care Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Cardiovascular Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[{"name":"Vanderbilt University Department of Biostatistics Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Allergy Pulmonary and Critical Care Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid W.","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Vanderbilt University Department of Biomedical Engineering Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Farber\u2010Eger","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Cardiovascular Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn S.","family":"Wells","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Cardiovascular Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Allergy Pulmonary and Critical Care Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan L.","family":"Brittain","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Cardiovascular Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0527"},{"key":"e_1_2_8_3_1","first-page":"1","article-title":"Pulmonary hypertension surveillance\u2009\u2010\u2009United States, 1980\u20132002","volume":"54","author":"Hyduk A","year":"2005","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0075"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/105864"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.051"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.052"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22579"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2016.04.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.033"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.036"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807265"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.061"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.19.2138"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6545a4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001264"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.06.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31177-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.09.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.8.923"},{"issue":"6","key":"e_1_2_8_22_1","article-title":"Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study","volume":"15","author":"Taylor HA","year":"2005","journal-title":"Ethn Dis"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084264"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0383OC"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911818"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005111"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2010.00175.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.89"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","unstructured":"Brittain EL and Chan SY. Integration of complex data sources to provide biologic insight into pulmonary vascular disease (2015 Grover Conference Series).Pulm Circ2016; 6(3): 251\u2013260.","DOI":"10.1086\/686995"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/688516"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.942"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020207"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.72"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/2043-9113-4-12"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0300"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001366"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0962"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0404"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130590.24107.D3"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200209000-00002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.4.652"},{"issue":"8","key":"e_1_2_8_46_1","first-page":"474","article-title":"Health insurance and racial disparities in pulmonary hypertension outcomes","volume":"23","author":"Parikh KS","year":"2017","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1821ST"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1653"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.01.012"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.028"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.11.1152"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.054"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902253400804"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894018764273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894018764273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894018764273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:54:07Z","timestamp":1693223647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894018764273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/2045894018764273"],"URL":"https:\/\/doi.org\/10.1177\/2045894018764273","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}