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Despite normal resting pulmonary artery pressures, patients with ePH demonstrate early pulmonary vascular changes with reduced pulmonary arterial compliance (PAC) and vascular distensibility (\u03b1). Recent data suggest that targeted vasodilator therapy may improve hemodynamics in ePH, but it is not well\u2010known whether such medications alter pulmonary vascular distensibility. Thus, we sought to evaluate if vasodilator therapy improved \u03b1 a marker of early pulmonary vascular disease in ePH. Ten patients performed supine exercise right heart catheterization (exRHC) with bicycle ergometer to peak exercise. Patients diagnosed with ePH were treated with pulmonary vasodilators. A repeat symptom\u2010limited exercise RHC was performed at least six months after therapy. Patients with ePH had evidence of early pulmonary vascular disease, as baseline PAC and \u03b1 were reduced. After pulmonary vasodilator therapy, a number of peak exercise hemodynamics statistically improved, including a decrease of total pulmonary resistance and pulmonary vascular resistance, while cardiac output increased. Importantly, vasodilator therapy partially reversed the pathogenic decreases of \u03b1 at the time of repeat exRHC. Pulmonary vascular distensibility, \u03b1, a marker of early pulmonary vascular disease, improves in ePH after therapy with pulmonary vasodilators.<\/jats:p>","DOI":"10.1177\/2045894018787381","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T11:36:42Z","timestamp":1529408202000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of exercise pulmonary hypertension improves pulmonary vascular distensibility"],"prefix":"10.1002","volume":"8","author":[{"given":"William D.","family":"Wallace","sequence":"first","affiliation":[{"name":"Heritage College of Osteopathic Medicine Ohio University Athens OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Nouraie","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh School of Medicine and 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