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Studies have confirmed that CHIP regulates cell growth, apoptosis, cell phenotype, metabolism, neurodegeneration, etc. However, whether CHIP is involved in pulmonary artery smooth muscle cell (PASMC) proliferation, a vital contributor to chronic hypoxia\u2010induced pulmonary hypertension (CHPH), remains unknown. In this study, we first evaluated CHIP expression in the pulmonary arteries (PAs) of CHPH model rats. Subsequently, by silencing CHIP, we investigated the effect of CHIP on hypoxia\u2010induced PASMC proliferation and the underlying mechanism. Our results showed that CHIP expression was upregulated in the PAs of CHPH model rats. Silencing CHIP significantly suppressed the hypoxia\u2010triggered promotion of proliferation, [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry (SOCE), and some regulators of SOCE such as TRPC1 and TRPC6\u00a0in cultured PASMCs. These results indicate that CHIP likely contributes to hypoxia\u2010induced PASMC proliferation by targeting the SOCE\u2010[Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> pathway through the regulation of TRPC1 and TRPC6\u00a0in the PASMCs. In conclusion, the findings of the current study clarify the role of CHIP in hypoxia\u2010induced PASMC proliferation.<\/jats:p>","DOI":"10.1177\/2045894019875343","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T06:26:40Z","timestamp":1566455200000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Inactivation of carboxyl terminus of Hsc70\u2010interacting protein prevents hypoxia\u2010induced pulmonary arterial smooth muscle cells proliferation by reducing intracellular Ca<sup>2+<\/sup> concentration"],"prefix":"10.1002","volume":"9","author":[{"given":"Fang","family":"Dong","sequence":"first","affiliation":[{"name":"College of Medicine and Health Lishui University Lishui Zhejiang People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College 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