{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:49:43Z","timestamp":1775058583583,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL139798"],"award-info":[{"award-number":["R01 HL139798"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stanley Manne Research Institute","award":["Fellow Grant"],"award-info":[{"award-number":["Fellow Grant"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL139798"],"award-info":[{"award-number":["R01 HL139798"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Bronchopulmonary dysplasia\u2010associated pulmonary hypertension (BPD\u2010PH) may either be concordant or discordant between multiple gestation births. Abnormal placental development, particularly maternal vascular malperfusion, may account for discordance in BPD\u2010PH through fetal programming mechanisms. Maternal vascular malperfusion is a placental histologic lesion associated with intrauterine growth restriction and BPD\u2010PH. We conducted a retrospective longitudinal cohort study of infants born &lt;29 weeks gestation with available placental histology at Prentice Women's Hospital in Chicago from 2005\u20132012. The primary outcome was discordant BPD\u2010PH associated with placental maternal vascular malperfusion. We secondarily assessed whether the risk of BPD\u2010PH and placental lesions was different among infants of multiple (compared to singleton) gestations. The cohort consisted of 135\u00a0multiple gestation infants and 355 singletons. In a separate cohort of 39 singletons and 35\u00a0multiples, associations between 12 cytokines and angiogenic growth factors in cord blood plasma for biomarker discordance, maternal vascular malperfusion, and bronchopulmonary dysplasia were explored. Among multiples, discordant maternal vascular malperfusion was not associated with BPD\u2010PH (OR\u2009=\u20091.9 (0.52, 6.9); <jats:italic>p<\/jats:italic>\u2009=\u20090.33) in infants exposed to placental maternal vascular malperfusion. However, singleton infants were more likely to develop BPD\u2010PH (compared to multiples) after adjusting for mode of delivery, chorioamnionitis, chronic hypertension, placental abruption, small\u2010for\u2010gestational age birth weight, and gestational age (aOR\u2009=\u20092.7 (1.2, 5.8); <jats:italic>p<\/jats:italic>\u2009=\u20090.038). Singletons were more likely to be small\u2010for\u2010gestational age (11% vs 4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and have placental lesions compared to their multiple\u2010gestation counterparts (96% vs 81%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), principally severe maternal vascular malperfusion (17% vs 4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and chronic inflammation (32% vs 11%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Increased risk of BPD\u2010PH in singleton pregnancies &lt;29 weeks gestation compared to multiples may be related to increased frequency of these histologic lesions. Placental pathology in singleton and multiple gestation pregnancies may serve as an early biomarker to predict BPD\u2010PH.<\/jats:p>","DOI":"10.1177\/2045894020910674","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T15:24:50Z","timestamp":1582125890000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia\u2010associated pulmonary hypertension"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-0219","authenticated-orcid":false,"given":"Andrew","family":"Franklin","sequence":"first","affiliation":[{"name":"Department of Pediatrics NorthShore University HealthSystem Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmita","family":"Yallapragada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Southwestern Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Birkett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Grobman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine NorthShore University HealthSystem Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-784X","authenticated-orcid":false,"given":"Karen","family":"Mestan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.01.009"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.213"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.03.024"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.09.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.05.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.130"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.01.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14251"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12833"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-8083-2"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.04.035"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479737"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.09.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.10.002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-92"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250103"},{"key":"e_1_2_12_19_1","first-page":"67","article-title":"ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists","volume":"77","author":"Practice ACoO","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609168713"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00475"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570379"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12829"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526618775958"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4918"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020910674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894020910674","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020910674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:28:21Z","timestamp":1693222101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894020910674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/2045894020910674"],"URL":"https:\/\/doi.org\/10.1177\/2045894020910674","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}