{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:06:18Z","timestamp":1783040778207,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Uncorrected atrial septal defect undergoes right ventricle chronic volume overload which may lead to pulmonary hypertension and Eisenmenger Syndrome. The soluble suppression of tumorigenicity\u20102 is a left ventricle strain biomarker; however, its role in right ventricle strain is unclear. This study aimed to investigate the implication of serum soluble suppression of tumorigenicity\u20102\u00a0in adult uncorrected atrial septal defect. This was a cross\u2010sectional study. We enrolled 81 adult uncorrected secundum atrial septal defect patients. Clinical and hemodynamic data were collected. Serum samples were withdrawn from the pulmonary artery during right heart catheterization. Serum soluble suppression of tumorigenicity\u20102 and NT\u2010proBNP levels were measured. Subjects were divided into three groups based on clinical and hemodynamic severity. The correlation of soluble suppression of tumorigenicity\u20102 with patients' data and comparison among groups were analyzed. A <jats:italic>p<\/jats:italic> value &lt;0.05 was considered statistically significant. Results showed that, there were significant correlations between serum soluble suppression of tumorigenicity\u20102 and mean pulmonary artery pressure (<jats:italic>r<\/jats:italic>\u2009=\u20090.203, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) and right ventricle end\u2010diastolic diameter (<jats:italic>r<\/jats:italic>\u2009=\u20090.203, <jats:italic>p<\/jats:italic> &lt;0.05). Median serum soluble suppression of tumorigenicity\u20102 level was incrementally increased from group I (atrial septal defect and no\u2010pulmonary hypertension), group II (left\u2010to\u2010right atrial septal defect and pulmonary hypertension), to group III (Eisenmenger Syndrome): (17.4\u2009ng\/mL, 21.8\u2009ng\/mL, and 29.4\u2009ng\/mL, respectively). A post\u2010hoc analysis showed that serum soluble suppression of tumorigenicity\u20102 level was significantly different between groups I and III (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Serum N terminal pro brain natriuretic peptide (NT\u2010proBNP) level was consistently associated with worse clinical and hemodynamic parameters. No correlation was found between serum soluble suppression of tumorigenicity\u20102 and NT\u2010proBNP level. In conclusion, serum soluble suppression of tumorigenicity\u20102 level had significant positive correlation with mean pulmonary artery pressure and right ventricle end\u2010diastolic diameter in uncorrected secundum atrial septal defect patients. Higher serum soluble suppression of tumorigenicity\u20102 level was associated with the presence of pulmonary hypertension and Eisenmenger Syndrome in uncorrected secundum atrial septal defect patients.<\/jats:p>","DOI":"10.1177\/2045894020915832","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T12:02:11Z","timestamp":1583928131000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum soluble suppression of tumorigenicity\u20102 level associates with severity of pulmonary hypertension associated with uncorrected atrial septal defect"],"prefix":"10.1002","volume":"10","author":[{"given":"Reza S.","family":"Pratama","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada \u2013 Dr. Sardjito Hospital Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1033","authenticated-orcid":false,"given":"Anggoro B.","family":"Hartopo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada \u2013 Dr. Sardjito Hospital Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyah W.","family":"Anggrahini","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada \u2013 Dr. Sardjito Hospital Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera C.","family":"Dewanto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada \u2013 Dr. Sardjito Hospital Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia K.","family":"Dinarti","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada \u2013 Dr. Sardjito Hospital Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_12_3_1","first-page":"93","article-title":"Atrial septal defects \u2013 clinical manifestations, echo assessment, and intervention","volume":"8","author":"Martin SS","year":"2014","journal-title":"Clin Med Insights Cardiol"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592386"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30634"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2660"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958223"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.09.010"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.12.016"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127958.21003.5A"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22262"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","unstructured":"Dinarti LK Hartopo AB Kusuma AD et al. The COngenital HeARt Disease in adult and Pulmonary Hypertension (COHARD\u2010PH) registry: a descriptive study from single\u2010center hospital registry of adult congenital heart disease and pulmonary hypertension in Indonesia.BMC Cardiovasc Disord2020; 20: 163.","DOI":"10.1186\/s12872-020-01434-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7526508"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.06.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.150953.5"},{"key":"e_1_2_12_17_1","first-page":"145","article-title":"Soluble ST2 testing: a promising biomarker in the management of heart failure","volume":"106","author":"Villacorta H","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.12.128"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1033"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.031"},{"key":"e_1_2_12_21_1","first-page":"111","article-title":"Prognostic stratification in pulmonary hypertension: a multi\u2010biomarker approach","volume":"36","author":"Pl\u00e1cido R","year":"2017","journal-title":"Rev Port Cardiol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340310793566154"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.05.101"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202406"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020915832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894020915832","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020915832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:39:24Z","timestamp":1693222764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894020915832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/2045894020915832"],"URL":"https:\/\/doi.org\/10.1177\/2045894020915832","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}