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These patients may manifest a spectrum of complications ranging from hematologic malignancy to chronic parenchymal lung disease. Regular immunoglobulin replacement therapy improves immunologic debility but does not mitigate other features of this disease. Here, we discuss a complication of common variable immunodeficiency not previously characterized in the literature. We present two cases of advanced pulmonary vascular disease associated with common variable immunodeficiency treated with pulmonary vasodilators.<\/jats:p>","DOI":"10.1177\/2045894020922792","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T08:35:08Z","timestamp":1586939708000},"page":"1-3","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence of pulmonary arterial hypertension in two patients with common variable immunodeficiency"],"prefix":"10.1002","volume":"10","author":[{"given":"Jessica","family":"Huston","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department Pathology Microbiology and Immunology Vanderbilt University Medical Center Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Medical Center Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Pugh","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Medical Center Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124545"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.012443"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.11.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0151-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.057"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.05.011"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020922792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894020922792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020922792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:40:22Z","timestamp":1693222822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894020922792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/2045894020922792"],"URL":"https:\/\/doi.org\/10.1177\/2045894020922792","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}