{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:12:20Z","timestamp":1789103540812,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Right ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right ventricular indices calculated using magnetic resonance imaging and right heart catheterization metrics in pulmonary arterial hypertension. We retrospectively collected data from 57\u00a0Japanese patients with pulmonary arterial hypertension and 18 controls and calculated six indices of right ventricular function: two indices of contractility (end\u2010systolic elastance calculated with right ventricular maximum pressure and with magnetic resonance imaging metrics); two indices of right ventricular\u2013pulmonary arterial coupling (end\u2010systolic elastance\/arterial elastance calculated with the pressure method (end\u2010systolic elastance\/arterial elastance (P)) and with the volume method (end\u2010systolic elastance\/arterial elastance (V)); and two indices of right ventricular diastolic function (stiffness (\u03b2) and end\u2010diastolic elastance). We compared the indices between controls and patients with pulmonary arterial hypertension and examined their prognostic role. In patients with pulmonary arterial hypertension, end\u2010systolic elastance (right ventricular maximum pressure) was higher (pulmonary arterial hypertension 0.94 (median) vs control 0.42 (mmHg\/mL), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), end\u2010systolic elastance\/arterial elastance (V) was lower (pulmonary arterial hypertension 0.72 vs control 1.69, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and \u03b2 and end\u2010diastolic elastance were significantly higher than those in the controls. According to the log\u2010rank test, end\u2010systolic elastance\/arterial elastance (P) and end\u2010diastolic elastance were significantly associated with the composite event rate. According to the multivariate Cox regression analysis, decreased end\u2010systolic elastance\/arterial elastance (P) was associated with a higher composite event rate (hazard ratio 11.510, 95% confidence interval: 1.954\u201367.808). In conclusion, an increased right ventricular contractility, diastolic dysfunction, and a trend of impaired right ventricular\u2013pulmonary arterial coupling were observed in our pulmonary arterial hypertension cohort. According to the multivariate outcome analysis, a decreased end\u2010systolic elastance\/arterial elastance (P), suggestive of impaired right ventricular\u2013pulmonary arterial coupling, best predicted the pulmonary arterial hypertension\u2010related event.<\/jats:p>","DOI":"10.1177\/2045894020957223","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T14:55:59Z","timestamp":1601909759000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Right ventriculo\u2013pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension"],"prefix":"10.1002","volume":"10","author":[{"given":"Toshitaka","family":"Nakaya","sequence":"first","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohira","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sato","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Watanabe","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Nishimura","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Oyama\u2010Manabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-6585","authenticated-orcid":false,"given":"Masaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Endocrinology and Nephrology Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi M.","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Statistical Data Science The Institute of Statistical Mathematics Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichizo","family":"Tsujino","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00006511"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.1.81"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.12.864"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01023.2002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001873"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300462"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00156714"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2271OC"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.015"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306142"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.985515"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00463-7"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.05.007"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-013-0286-7"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10262"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.022"},{"key":"e_1_2_13_20_1","first-page":"H1287","article-title":"Matching dicrotic notch and mean pulmonary artery pressures: implications for effective arterial elastance","volume":"271","author":"Chemla D","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00178.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000008"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2365OC"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01900-2018"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1195LE"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9607123"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.3.483"},{"key":"e_1_2_13_28_1","first-page":"1941","article-title":"High prevalence of right ventricular systolic dysfunction in early systemic sclerosis","volume":"31","author":"Meune C","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022082"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01240.2005"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002636"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020957223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894020957223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020957223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:17:46Z","timestamp":1693228666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894020957223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/2045894020957223"],"URL":"https:\/\/doi.org\/10.1177\/2045894020957223","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}