{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:11:46Z","timestamp":1769692306953,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Peking union medical college hospital of medical novel medical technology project","award":["No. XJS20190210"],"award-info":[{"award-number":["No. XJS20190210"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["NO. 2020-2-40111"],"award-info":[{"award-number":["NO. 2020-2-40111"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Several animal studies have shown that regional lung perfusion could be effectively estimated by the hypertonic saline contrast electrical impedance tomography method. Here, we reported an application of this method to dynamically assess regional pulmonary perfusion defect in a patient with acute massive pulmonary embolism. A 68\u2010year\u2010old man experienced sudden dyspnea and cardiac arrest during out\u2010of\u2010bed physical activity on the first day after partial mediastinal tumor resection. Acute pulmonary embolism was suspected due to acute enlargement of right heart and fixed inferior venous cava measured with bedside ultrasound. The computed tomography pulmonary angiography further confirmed large embolism in both left and right main pulmonary arteries and branches. The regional time impedance curves, which were obtained by a bolus of 10\u00a0ml 10% NaCl through the central venous catheter, were then analyzed to quantitatively assess regional perfusion. Normal ventilation distribution with massive defects in regional perfusion in both lungs was observed, leading to a ventilation\u2013perfusion mismatch and low oxygenation index (PaO<jats:sub>2<\/jats:sub>\/FiO2\u2009=\u200986\u00a0mmHg) at the first day of pulmonary embolism. The anticoagulation was performed with heparin, and the patient\u2019s condition (such as shock, dyspnea, hypoxemia, etc.), regional lung perfusion defect, and ventilation\u2013perfusion mismatch continuously improved in the following days. In conclusion, this case implies that electrical impedance tomography might have the potential to assess and monitor regional perfusion for rapid diagnosis of fatal pulmonary embolism in clinical practice.<\/jats:p>","DOI":"10.1177\/2045894020984043","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:11:05Z","timestamp":1607731865000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Rapid dynamic bedside assessment of pulmonary perfusion defect by electrical impedance tomography in a patient with acute massive pulmonary embolism"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-1282","authenticated-orcid":false,"given":"Siyi","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiwu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9z","family":"Frerichs","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University Medical Center of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-2207","authenticated-orcid":false,"given":"Zhanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University Xi\u2019an China"},{"name":"Institute of Technical Medicine Furtwangen University Villingen\u2010Schwenningen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.800585"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01090.2010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.04.056"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/36\/6\/1297"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-1780LE"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2291"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08826.x"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020984043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2045894020984043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2045894020984043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:32:59Z","timestamp":1693200779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2045894020984043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/2045894020984043"],"URL":"https:\/\/doi.org\/10.1177\/2045894020984043","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}