{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:07:31Z","timestamp":1748336851706,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Science and Technology Information System of the People\u2019s Republic of China","award":["2018YFC1313603"],"award-info":[{"award-number":["2018YFC1313603"]}]},{"name":"Program of Natural Science Foundation of Shanghai","award":["18ZR1431500"],"award-info":[{"award-number":["18ZR1431500"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Cardiopulmonary exercise testing and pulmonary function test are important methods for detecting human cardio\u2010pulmonary function. Whether they could screen vasoresponsiveness in idiopathic pulmonary artery hypertension (IPAH) patients remains undefined. One hundred thirty\u2010two IPAH patients with complete data were retrospectively enrolled. Patients were classified as vasodilator\u2010responsive (VR) group and vasodilator\u2010nonresponsive (VNR) group on the basis of the acute vasodilator test. Pulmonary function test and cardiopulmonary exercise testing were assessed subsequently and all patients were confirmed by right heart catheterization. We analyzed cardiopulmonary exercise testing and pulmonary function test data and derived a prediction rule to screen vasodilator\u2010responsive patients in IPAH. Nineteen of VR\u2010IPAH and 113 of VNR\u2010IPAH patients were retrospectively enrolled. Compared with VNR\u2010IPAH patients, VR\u2010IPAH patients had less severe hemodynamic effects (lower RAP, m PAP, PAWP, and PVR). And VR\u2010IPAH patients had higher anaerobic threshold (AT), peak partial pressure of end\u2010tidal carbon dioxide (P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub>), oxygen uptake efficiency (OUEP), and FEV<jats:sub>1<\/jats:sub>\/FVC (P all &lt;0.05), while lower peak partial pressure of end\u2010tidal oxygen (P<jats:sub>ET<\/jats:sub>O<jats:sub>2<\/jats:sub>) and\u2009minute ventilation (VE)\/carbon dioxide output (VCO<jats:sub>2<\/jats:sub>) slope (P all &lt;0.05). FEV<jats:sub>1<\/jats:sub>\/FVC (Odds Ratio [OR]: 1.14, 95% confidence interval [CI]: 1.02\u20131.26, P\u2009=\u20090.02) and PeakP<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> (OR: 1.13, 95% CI: 1.01\u20131.26, P\u2009=\u20090.04) were independent predictors of VR adjusted for age, sex, and body mass index. A novel formula (=\u221216.17\u2009+\u20090.123\u2009\u00d7\u2009PeakP<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub>\u2009+\u20090.127\u00d7FEV<jats:sub>1<\/jats:sub>\/FVC) reached a high area under the curve value of 0.8 (P\u2009=\u20090.003). Combined with these parameters, the optimal cutoff value of this model for detection of VR is \u22121.06, with a specificity of 91% and sensitivity of 67%. Compared with VNR\u2010IPAH patients, VR\u2010IPAH patients had less severe hemodynamic effects. Higher FEV<jats:sub>1<\/jats:sub>\/FVC and higher peak P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> were associated with increased odds for vasoresponsiveness. A novel score combining PeakP<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> and FEV<jats:sub>1<\/jats:sub>\/FVC provides high specificity to predict VR patients among IPAH.<\/jats:p>","DOI":"10.1177\/20458940211059713","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T13:45:37Z","timestamp":1635774337000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["PeakP<sub>ET<\/sub>CO<sub>2<\/sub> combined with FEV1\/FVC predicts vasodilator\u2010responsive patients with idiopathic pulmonary arterial hypertension"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-5494","authenticated-orcid":false,"given":"Ci\u2010Jun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4062-5550","authenticated-orcid":false,"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Gang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Function Test Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-041717-085955"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.010"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.488486"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.09.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc2901.093198"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S152971"},{"key":"e_1_2_13_8_1","first-page":"41","article-title":". 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