{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:40Z","timestamp":1793831260240,"version":"4.6.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH\/NCATS Colorado CTSA","award":["Grant Number UL1 TR00253"],"award-info":[{"award-number":["Grant Number UL1 TR00253"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Development of pulmonary hypertension (PH) in patients with left side heart disease (LHD) is a predictor of poor prognosis. The use of pulmonary vasodilators in PH associated with LHD (PH\u2010LHD) is controversial. In this study, we describe the practice patterns regarding the use of pulmonary vasodilators in PH\u2010LHD among a group of international pediatric PH specialists. A survey was distributed to the members of three pediatric PH networks: PPHNet, PVRI, and REHIPED. The survey queried participants on the rationale, indications, and contraindications of the use of pulmonary vasodilators in children with PH\u2010LHD. Forty\u2010seven PH specialists from 39\u00a0PH centers completed the survey. Participants included PH specialists from North America (57%), South America (15%), and Europe (19%). The majority of participants (74%) recommended the use of pulmonary vasodilators only in patients with combined pre\u2010capillary and post\u2010capillary pulmonary hypertension. Participants required the presence of clinical symptoms or signs of heart failure (68%) or right ventricular dysfunction by echocardiography (51%) in order to recommend pulmonary vasodilator therapy. There was no agreement regarding hemodynamic criteria used to recommend pulmonary vasodilators or the etiologies of LHD considered contraindications for using pulmonary vasodilators to manage PH\u2010LHD. Of the available PH\u2010targeted drugs, most participants preferred the use of phosphodiesterase\u20105\u2010inhibitors for this indication. In conclusion, the practice of recommending pulmonary vasodilators in PH\u2010LHD is highly variable among international pediatric PH specialists. Most specialists of those surveyed (57% in North America) would consider the use of pulmonary vasodilators in PH\u2010LHD only if pre\u2010capillary pulmonary hypertension and right ventricular dysfunction are present.<\/jats:p>","DOI":"10.1177\/2045894021991446","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T11:02:37Z","timestamp":1613214157000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers"],"prefix":"10.1002","volume":"11","author":[{"given":"Hythem","family":"Nawaytou","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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