{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:47:19Z","timestamp":1772268439613,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Sleep\u2010related breathing disorders, including sleep apnea and hypoxemia during sleep, are common in pulmonary arterial hypertension, but the underlying mechanisms remain unknown. Overnight fluid shift from the legs to the upper airway and to the lungs promotes obstructive and central sleep apnea, respectively, in fluid\u2010retaining states. The main objective was to evaluate if overnight rostral fluid shift from the legs to the upper part of the body is associated with sleep\u2010related breathing disorders in pulmonary arterial hypertension. In a prospective study, a group of stable patients with idiopathic, heritable, related to drugs, toxins, or treated congenital heart disease pulmonary arterial hypertension underwent a polysomnography and overnight fluid shift measurement by bioelectrical impedance in the month preceding or following a one\u2010day hospitalization according to regular pulmonary arterial hypertension follow\u2010up schedule with a right heart catheterization. Results show that among 15 patients with pulmonary arterial hypertension (women: 87%; median (25\u201375th percentiles); age: 40 (32\u201361) years; mean pulmonary arterial pressure 56 (46\u201368)\u2009mmHg; pulmonary vascular resistance 8.8 (6.4\u201310.1) Wood units), two patients had sleep apnea and eight (53%) had hypoxemia during sleep without apnea. The overnight rostral fluid shift was 168 (118\u2013263) mL per leg. Patients with hypoxemia during sleep had a greater fluid shift (221 (141\u2013 361) mL) than those without hypoxemia (118 (44\u2013178) mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). In conclusion, this pilot study suggests that hypoxemia during sleep is associated with overnight rostral fluid shift in pulmonary arterial hypertension.<\/jats:p>","DOI":"10.1177\/2045894021996930","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T11:49:16Z","timestamp":1613389756000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypoxemia during sleep and overnight rostral fluid shift in pulmonary arterial hypertension: a pilot study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1890","authenticated-orcid":false,"given":"Etienne\u2010Marie","family":"Jutant","sequence":"first","affiliation":[{"name":"School of Medicine Universit\u00e9 Paris\u2010Saclay Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"},{"name":"Department of Respiratory and Intensive Care Medicine Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Pulmonary Hypertension National Referral Center H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"School of Medicine Universit\u00e9 Paris\u2010Saclay Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"},{"name":"Department of Respiratory and Intensive Care Medicine Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Pulmonary Hypertension National Referral Center H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre 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