{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:56:15Z","timestamp":1793310975514,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Previous studies have provided inconsistent results about the cardiovascular risks for participants with metabolically healthy obesity (MHO). These uncertainties might partly reflect the lack of a uniform definition of MHO. We conducted a systematic review and meta-analysis to examine whether there is a suitable approach that identifies obese participants who are not at an increased risk of cardiovascular events compared with healthy normal-weight participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Twenty-two prospective studies were eligible for the meta-analysis. Using random-effect models, pooled relative risks (RRs) were calculated for the combined effects of obesity with the presence or absence of metabolic syndrome, insulin resistance, hypertension, diabetes, hyperlipidaemia and any of these metabolic factors. Participants with MHO defined by the absence of metabolic syndrome were at increased risk for cardiovascular events compared with healthy normal-weight participants (pooled RR 1.45, 95% confidence interval (CI) 1.20\u20131.70), but had lower risks than unhealthy normal-weight (RR 2.07, 95% CI 1.62\u20132.65) and obese (RR 2.31, 95% CI 1.99\u20132.69) participants. The risk associated with participants who had MHO was particularly high over the long term. Similar risk estimates were observed when MHO was defined by other approaches.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>None of the approaches clearly identified an obese subgroup not at increased risk of cardiovascular events compared with normal-weight healthy participants. A benign obese phenotype might be defined by strict definitions, but insufficient studies exist to support this. More research is needed to better define MHO.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2047487315623884","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T02:25:18Z","timestamp":1450923918000},"page":"956-966","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":356,"title":["Metabolically healthy obesity and cardiovascular events: A systematic\n                    review and meta-analysis"],"prefix":"10.1093","volume":"23","author":[{"given":"Nathalie","family":"Eckel","sequence":"first","affiliation":[{"name":"Department of Molecular Epidemiology , German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Germany"},{"name":"German Center for Diabetes Research , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Meidtner","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology , German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kalle-Uhlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Stefan","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research , Germany"},{"name":"Institute of Diabetes Research and Metabolic Diseases of the Helmholtz Center M\u00fcnchen at the University of T\u00fcbingen , Germany"},{"name":"Department of Internal Medicine IV , University Hospital of T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias B","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology , German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Germany"},{"name":"German Center for Diabetes Research , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"2022112313000010300_bibr1-2047487315623884","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"2022112313000010300_bibr2-2047487315623884"},{"key":"2022112313000010300_bibr3-2047487315623884","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national\n                        prevalence of overweight and obesity in children and adults during\n                        1980\u20132013: a systematic analysis for the Global Burden of Disease\n                        Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"2022112313000010300_bibr4-2047487315623884","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nature05487","article-title":"Mechanisms linking obesity with cardiovascular\n                        disease","volume":"444","author":"Van\n                                Gaal","year":"2006","journal-title":"Nature"},{"key":"2022112313000010300_bibr5-2047487315623884","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and\n                        cause-specific mortality in 900 000 adults: collaborative analyses of 57\n                        prospective studies","volume":"373","author":"Whitlock","year":"2009","journal-title":"Lancet"},{"key":"2022112313000010300_bibr6-2047487315623884","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/1741826711412039","article-title":"Relationships between body mass\n                        index, cardiovascular mortality, and risk factors: a report from the SCORE\n                        investigators","volume":"18","author":"Dudina","year":"2011","journal-title":"Eur J Cardiovasc Prev\n                        Rehabil"},{"key":"2022112313000010300_bibr7-2047487315623884","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/archinte.168.15.1617","article-title":"The obese without\n                        cardiometabolic risk factor clustering and the normal weight with\n                        cardiometabolic risk factor clustering: prevalence and correlates of 2\n                        phenotypes among the US population (NHANES\n                    1999\u20132004)","volume":"168","author":"Wildman","year":"2008","journal-title":"Arch Intern Med"},{"key":"2022112313000010300_bibr8-2047487315623884","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1001\/archinte.168.15.1609","article-title":"Identification and\n                        characterization of metabolically benign obesity in humans","volume":"168","author":"Stefan","year":"2008","journal-title":"Arch Intern Med"},{"key":"2022112313000010300_bibr9-2047487315623884","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/obr.12198","article-title":"The prevalence of metabolically\n                        healthy obesity: a systematic review and critical evaluation of the\n                        definitions used","volume":"15","author":"Rey-Lopez","year":"2014","journal-title":"Obes Rev"},{"key":"2022112313000010300_bibr10-2047487315623884","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S2213-8587(13)70062-7","article-title":"Metabolically healthy obesity:\n                        epidemiology, mechanisms, and clinical implications","volume":"1","author":"Stefan","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022112313000010300_bibr11-2047487315623884","doi-asserted-by":"crossref","first-page":"758","DOI":"10.7326\/0003-4819-159-11-201312030-00008","article-title":"Are metabolically healthy overweight and obesity benign\n                        conditions? A systematic review and meta-analysis","volume":"159","author":"Kramer","year":"2013","journal-title":"Ann Intern Med"},{"key":"2022112313000010300_bibr12-2047487315623884","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1038\/oby.2006.269","article-title":"Reverse causality and\n                        confounding and the associations of overweight and obesity with\n                        mortality","volume":"14","author":"Lawlor","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"2022112313000010300_bibr13-2047487315623884","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational\n                        studies in epidemiology: a proposal for reporting. Meta-analysis Of\n                        Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"2022112313000010300_bibr14-2047487315623884"},{"key":"2022112313000010300_bibr15-2047487315623884","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/jamainternmed.2013.10522","article-title":"Myocardial infarction and ischemic heart disease in\n                        overweight and obesity with and without metabolic syndrome","volume":"174","author":"Thomsen","year":"2014","journal-title":"JAMA Intern Med"},{"key":"2022112313000010300_bibr16-2047487315623884","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3945\/ajcn.112.040006","article-title":"Prognostic implications for\n                        insulin-sensitive and insulin-resistant normal-weight and obese individuals\n                        from a population-based cohort","volume":"96","author":"Bo","year":"2012","journal-title":"Am J Clin\n                        Nutr"},{"key":"2022112313000010300_bibr17-2047487315623884","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jacc.2013.11.035","article-title":"Risk of myocardial infarction\n                        and heart failure among metabolically healthy but obese individuals: HUNT\n                        (Nord-Trondelag Health Study), Norway","volume":"63","author":"Morkedal","year":"2014","journal-title":"J Am Coll\n                        Cardiol"},{"key":"2022112313000010300_bibr18-2047487315623884","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2337\/diacare.28.2.391","article-title":"Metabolic syndrome, obesity,\n                        and mortality: impact of cardiorespiratory fitness","volume":"28","author":"Katzmarzyk","year":"2005","journal-title":"Diabetes Care"},{"key":"2022112313000010300_bibr19-2047487315623884","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in\n                        meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"2022112313000010300_bibr20-2047487315623884","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/bmj.323.7304.101","article-title":"Systematic reviews in health care: investigating and dealing\n                        with publication and other biases in meta-analysis","volume":"323","author":"Sterne","year":"2001","journal-title":"BMJ"},{"key":"2022112313000010300_bibr21-2047487315623884","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.2337\/dc12-1654","article-title":"Metabolically healthy obesity\n                        and risk of mortality: does the definition of metabolic health\n                        matter?","volume":"36","author":"Hinnouho","year":"2013","journal-title":"Diabetes Care"},{"key":"2022112313000010300_bibr22-2047487315623884","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/eurheartj\/ehu123","article-title":"Metabolically healthy obesity\n                        and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II\n                        cohort study","volume":"36","author":"Hinnouho","year":"2015","journal-title":"Eur Heart J"},{"key":"2022112313000010300_bibr23-2047487315623884","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jacc.2011.04.047","article-title":"Increased heart failure risk in\n                        normal-weight people with metabolic syndrome compared with metabolically\n                        healthy obese individuals","volume":"58","author":"Voulgari","year":"2011","journal-title":"J Am Coll\n                        Cardiol"},{"key":"2022112313000010300_bibr24-2047487315623884","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/jech.2009.094110","article-title":"Mortality from ischaemic heart disease: age-specific effects\n                        of blood pressure stratified by body-mass index: the HUNT cohort study in\n                        Norway","volume":"65","author":"Morkedal","year":"2011","journal-title":"J Epidemiol Community Health"},{"key":"2022112313000010300_bibr25-2047487315623884","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/CIRCULATIONAHA.109.887521","article-title":"Impact of body mass index and\n                        the metabolic syndrome on the risk of cardiovascular disease and death in\n                        middle-aged men","volume":"121","author":"Arnlov","year":"2010","journal-title":"Circulation"},{"key":"2022112313000010300_bibr26-2047487315623884","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1161\/CIRCULATIONAHA.107.759951","article-title":"Obesity, behavioral lifestyle\n                        factors, and risk of acute coronary events","volume":"117","author":"Jensen","year":"2008","journal-title":"Circulation"},{"key":"2022112313000010300_bibr27-2047487315623884","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.ijo.0802060","article-title":"Influence of obesity on\n                        cardiovascular risk. Twenty-three-year follow-up of 22,025 men from an urban\n                        Swedish population","volume":"26","author":"Jonsson","year":"2002","journal-title":"Int J Obes Relat Metab\n                        Disord"},{"key":"2022112313000010300_bibr28-2047487315623884","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00004872-200303000-00017","article-title":"Body mass index, hypertension\n                        and 5-year coronary heart disease incidence in middle aged men: the PRIME\n                        study","volume":"21","author":"Mahamat","year":"2003","journal-title":"J Hypertens"},{"key":"2022112313000010300_bibr29-2047487315623884","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1210\/jc.2013-2832","article-title":"Risk of developing diabetes and\n                        cardiovascular disease in metabolically unhealthy normal-weight and\n                        metabolically healthy obese individuals","volume":"99","author":"Aung","year":"2014","journal-title":"J Clin\n                        Endocrinol Metab"},{"key":"2022112313000010300_bibr30-2047487315623884","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.amjcard.2007.06.073","article-title":"Comparison of usefulness of\n                        body mass index versus metabolic risk factors in predicting 10-year risk of\n                        cardiovascular events in women","volume":"100","author":"Song","year":"2007","journal-title":"Am J\n                        Cardiol"},{"key":"2022112313000010300_bibr31-2047487315623884","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1210\/jc.2006-0594","article-title":"Body mass index, metabolic\n                        syndrome, and risk of type 2 diabetes or cardiovascular\n                        disease","volume":"91","author":"Meigs","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2022112313000010300_bibr32-2047487315623884","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.282.16.1547","article-title":"Relationship between low\n                        cardiorespiratory fitness and mortality in normal-weight, overweight, and\n                        obese men","volume":"282","author":"Wei","year":"1999","journal-title":"JAMA"},{"key":"2022112313000010300_bibr33-2047487315623884","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/oby.2011.243","article-title":"Incident cardiovascular disease\n                        events in metabolically benign obese individuals","volume":"20","author":"Ogorodnikova","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"2022112313000010300_bibr34-2047487315623884","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ypmed.2005.09.011","article-title":"Independent effect and\n                        population impact of obesity on fatal coronary heart disease in\n                        adults","volume":"42","author":"Mann","year":"2006","journal-title":"Prev Med"},{"key":"2022112313000010300_bibr35-2047487315623884","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.2337\/dc12-1971","article-title":"Diabetes and cardiovascular\n                        disease outcomes in the metabolically healthy obese phenotype: a cohort\n                        study","volume":"36","author":"Appleton","year":"2013","journal-title":"Diabetes Care"},{"key":"2022112313000010300_bibr36-2047487315623884","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1503\/cmaj.1040834","article-title":"Insulin resistance syndrome,\n                        body mass index and the risk of ischemic heart disease","volume":"172","author":"St-Pierre","year":"2005","journal-title":"CMAJ"},{"key":"2022112313000010300_bibr37-2047487315623884","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.amjcard.2010.09.034","article-title":"Effect of different obesity\n                        phenotypes on cardiovascular events in Tehran Lipid and Glucose Study\n                        (TLGS)","volume":"107","author":"Hosseinpanah","year":"2011","journal-title":"Am J Cardiol"},{"key":"2022112313000010300_bibr38-2047487315623884","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ijo.2010.131","article-title":"Body mass index, weight change\n                        and risk of stroke and stroke subtypes: the Japan Public Health Center-based\n                        prospective (JPHC) study","volume":"35","author":"Saito","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"2022112313000010300_bibr39-2047487315623884","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1001\/archinte.162.22.2557","article-title":"Body mass index and the risk of\n                        stroke in men","volume":"162","author":"Kurth","year":"2002","journal-title":"Arch Intern Med"},{"key":"2022112313000010300_bibr40-2047487315623884","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jama.1997.03540430051032","article-title":"A prospective study of body\n                        mass index, weight change, and risk of stroke in women","volume":"277","author":"Rexrode","year":"1997","journal-title":"JAMA"},{"key":"2022112313000010300_bibr41-2047487315623884","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1056\/NEJM199003293221303","article-title":"A prospective study of obesity\n                        and risk of coronary heart disease in women","volume":"322","author":"Manson","year":"1990","journal-title":"N Engl\n                        J Med"},{"key":"2022112313000010300_bibr42-2047487315623884","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1016\/j.orcp.2010.01.001","article-title":"Body mass index, waist\n                        circumference, and risk of coronary heart disease: a prospective study among\n                        men and women","volume":"4","author":"Flint","year":"2010","journal-title":"Obes Res Clin Pract"},{"key":"2022112313000010300_bibr43-2047487315623884","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1161\/CIRCULATIONAHA.107.739714","article-title":"Abdominal obesity and the risk\n                        of all-cause, cardiovascular, and cancer mortality: sixteen years of\n                        follow-up in US women","volume":"117","author":"Zhang","year":"2008","journal-title":"Circulation"},{"key":"2022112313000010300_bibr44-2047487315623884","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/sj.ijo.0803339","article-title":"Sex differences in the\n                        relationships between BMI, WHR and incidence of cardiovascular disease: a\n                        population-based cohort study","volume":"30","author":"Li","year":"2006","journal-title":"Int J Obes\n                        (Lond)"},{"key":"2022112313000010300_bibr45-2047487315623884","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1001\/archinte.160.14.2117","article-title":"Associations of general and\n                        abdominal obesity with multiple health outcomes in older women: the Iowa\n                        Women's Health Study","volume":"160","author":"Folsom","year":"2000","journal-title":"Arch Intern Med"},{"key":"2022112313000010300_bibr46-2047487315623884","first-page":"S2","article-title":"US weight guidelines: is it also important to consider\n                        cardiorespiratory fitness?","volume":"22","author":"Lee","year":"1998","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2022112313000010300_bibr47-2047487315623884","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCHEARTFAILURE.112.000088","article-title":"Cardiorespiratory fitness, body\n                        mass index, and heart failure mortality in men: Cooper Center Longitudinal\n                        Study","volume":"6","author":"Farrell","year":"2013","journal-title":"Circ Heart Fail"},{"key":"2022112313000010300_bibr48-2047487315623884","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.ijcard.2013.07.230","article-title":"Combined effect of obesity and\n                        cardio-metabolic abnormality on the risk of cardiovascular disease: a\n                        meta-analysis of prospective cohort studies","volume":"168","author":"Fan","year":"2013","journal-title":"Int J\n                        Cardiol"},{"key":"2022112313000010300_bibr49-2047487315623884","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2458-14-14","article-title":"Beyond BMI: the\n                        \u201cmetabolically healthy obese\u201d phenotype & its association\n                        with clinical\/subclinical cardiovascular disease and all-cause mortality\n                        \u2013 a systematic review","volume":"14","author":"Roberson","year":"2014","journal-title":"BMC Public\n                        Health"},{"key":"2022112313000010300_bibr50-2047487315623884","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ejcn.2010.114","article-title":"Metabolically healthy obesity:\n                        different prevalences using different criteria","volume":"64","author":"Velho","year":"2010","journal-title":"Eur\n                        J Clin Nutr"},{"key":"2022112313000010300_bibr51-2047487315623884","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1161\/01.CIR.0000132467.45278.59","article-title":"Should C-reactive protein be added to metabolic syndrome and\n                        to assessment of global cardiovascular risk?","volume":"109","author":"Ridker","year":"2004","journal-title":"Circulation"},{"key":"2022112313000010300_bibr52-2047487315623884","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1177\/2047487313494028","article-title":"Metabolic syndrome in the\n                        prediction of cardiovascular events: the potential additive role of hsCRP\n                        and adiponectin","volume":"21","author":"Santaniemi","year":"2014","journal-title":"Eur J Prev Cardiol"},{"key":"2022112313000010300_bibr53-2047487315623884","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1155\/2012\/456456","article-title":"Does inflammation determine whether obesity is metabolically\n                        healthy or unhealthy? The aging perspective","volume":"2012","author":"Alam","year":"2012","journal-title":"Mediators Inflamm"},{"key":"2022112313000010300_bibr54-2047487315623884","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1007\/s00125-013-3040-8","article-title":"Tipping the inflammatory balance: inflammasome activation\n                        distinguishes metabolically unhealthy from healthy obesity","volume":"56","author":"Stienstra","year":"2013","journal-title":"Diabetologia"},{"key":"2022112313000010300_bibr55-2047487315623884","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1210\/jc.2007-2724","article-title":"High adiponectin concentrations\n                        are associated with the metabolically healthy obese\n                        phenotype","volume":"93","author":"Aguilar-Salinas","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2022112313000010300_bibr56-2047487315623884","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2009.06.020","article-title":"Metabolically healthy but obese\n                        individuals: relationship with hepatic enzymes","volume":"59","author":"Messier","year":"2010","journal-title":"Metabolism"},{"key":"2022112313000010300_bibr57-2047487315623884","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1001\/archinte.167.16.1720","article-title":"Association of overweight with\n                        increased risk of coronary heart disease partly independent of blood\n                        pressure and cholesterol levels: a meta-analysis of 21 cohort studies\n                        including more than 300 000 persons","volume":"167","author":"Bogers","year":"2007","journal-title":"Arch Intern\n                        Med"},{"key":"2022112313000010300_bibr58-2047487315623884","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0140-6736(13)61836-X","article-title":"Metabolic mediators of the\n                        effects of body-mass index, overweight, and obesity on coronary heart\n                        disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8\n                        million participants","volume":"383","author":"Lu","year":"2014","journal-title":"Lancet"},{"key":"2022112313000010300_bibr59-2047487315623884","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1210\/jc.2012-4253","article-title":"Metabolically healthy but\n                        obese, a matter of time? Findings from the prospective Pizarra\n                        study","volume":"98","author":"Soriguer","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2022112313000010300_bibr60-2047487315623884","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/oby.2012.69","article-title":"From metabolic normality to\n                        cardiometabolic risk factors in subjects with obesity","volume":"20","author":"Bobbioni-Harsch","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"2022112313000010300_bibr61-2047487315623884","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1467-789X.2012.01033.x","article-title":"Beyond the body mass index:\n                        tracking body composition in the pathogenesis of obesity and the metabolic\n                        syndrome","volume":"13","author":"Muller","year":"2012","journal-title":"Obes Rev"},{"key":"2022112313000010300_bibr62-2047487315623884","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ejcn.2013.61","article-title":"General and abdominal obesity\n                        parameters and their combination in relation to mortality: a systematic\n                        review and meta-regression analysis","volume":"67","author":"Carmienke","year":"2013","journal-title":"Eur J Clin\n                        Nutr"},{"key":"2022112313000010300_bibr63-2047487315623884","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(11)60105-0","article-title":"Separate and combined\n                        associations of body-mass index and abdominal adiposity with cardiovascular\n                        disease: collaborative analysis of 58 prospective studies","volume":"377","author":"Wormser","year":"2011","journal-title":"Lancet"},{"key":"2022112313000010300_bibr64-2047487315623884","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.pcad.2013.09.002","article-title":"Fitness vs. fatness on\n                        all-cause mortality: a meta-analysis","volume":"56","author":"Barry","year":"2014","journal-title":"Prog\n                        Cardiovasc Dis"},{"key":"2022112313000010300_bibr65-2047487315623884","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1467-789X.2007.00347.x","article-title":"A comparison of direct vs.\n                        self-report measures for assessing height, weight and body mass index: a\n                        systematic review","volume":"8","author":"Connor\n                                Gorber","year":"2007","journal-title":"Obes Rev"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2047487315623884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2047487315623884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/23\/9\/956\/47220292\/eurjpc0956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/23\/9\/956\/47220292\/eurjpc0956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T13:00:56Z","timestamp":1669208456000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/23\/9\/956\/5927395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,8,29]]},"published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1177\/2047487315623884","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,6,1]]},"published":{"date-parts":[[2016,6,1]]}}}