{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:17:48Z","timestamp":1789870668639,"version":"4.0.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early detection of risk factors for left ventricular (LV) dysfunction may be useful in patients with high blood pressure (HBP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patient from an outpatient HBP clinic underwent a two-dimensional Doppler-coupled echocardiography with determination of LV global longitudinal strain (GLS) by speckle-tracking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 200 patients (mean age 61.7\u2009\u00b1\u20099.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. LV hypertrophy (LVH) was found in 136 patients (68%), including concentric (n\u2009=\u2009106) and eccentric (n\u2009=\u200930) LVH. Diastolic dysfunction patterns were observed in 178 patients (89%), and increased filling pressures were observed in 37 patients (18.5%). GLS ranged from \u201325% to \u201311.6% (mean \u201316.9\u2009\u00b1\u20093.2%). Low GLS values (&amp;gt;\u201317%) were found in 91 patients (45.5%), 68 with and 23 without LVH. In univariate analysis, a reduced GLS was associated with HBP lasting for &amp;gt;10 years (odds ratio (OR)\u2009=\u20093.51, 95% confidence interval (CI) 1.73\u20137.09; p\u2009=\u20090.002), uncontrolled HBP (OR\u2009=\u20093.55, 95% CI 1.96\u20136.43; p\u2009&amp;lt;\u20090.0001), overweight (OR\u2009=\u20092.01, 95% CI 0.93\u20134.31; p\u2009=\u20090.0028), diabetes (OR\u2009=\u20092.21, 95% CI 1.25\u20133.90; p\u2009=\u20090.006), dyslipidemia (OR\u2009=\u20092.16, 95% CI 1.22\u20133.84; p\u2009=\u20090.008), renal failure (OR\u2009=\u20094.27, 95% CI 1.80\u201310.10; p\u2009=\u20090.001), an increased Cornell index (OR\u2009=\u20093.70, 95% CI 1.98\u20136.90; p\u2009&amp;lt;\u20090.0001), concentric LVH (OR\u2009=\u20099.26, 95% CI 2.62\u201332.73; p\u2009=\u20090.001), remodeling (OR\u2009=\u20098.51, 95% CI 2.18\u201333.23; p\u2009=\u20090.002), and filling pressures (OR\u2009=\u20097.1, 95% CI 2.9\u201317.3; p\u2009&amp;lt;\u20090.0001). In multivariable analysis, duration of HBP (p\u2009=\u20090.038), uncontrolled BP (p\u2009=\u20090.006), diabetes (p\u2009=\u20090.023), LVH (p\u2009=\u20090.001), and increased filling pressures (p\u2009=\u20090.003) remained associated with GLS decline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Early impairment of LV function, detected by a reduced GLS, is associated with long-lasting, uncontrolled HBP, overweight, related metabolic changes, and is more pronounced in patients with LVH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2047487317721644","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:40:54Z","timestamp":1500626454000},"page":"1463-1472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Factors associated with global longitudinal strain decline in hypertensive patients with normal left ventricular ejection fraction"],"prefix":"10.1093","volume":"24","author":[{"given":"Nabila","family":"Soufi Taleb Bendiab","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Aboubekr Belkaid University Hospital Tlemcen, Tlemcen, Algeria"},{"name":"COCRG, Cardiology Oncology Research Collaborative Group (CORCG), Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahim","family":"Meziane-Tani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Aboubekr Belkaid University Hospital Tlemcen, Tlemcen, Algeria"},{"name":"COCRG, Cardiology Oncology Research Collaborative Group (CORCG), Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souhila","family":"Ouabdesselam","sequence":"additional","affiliation":[{"name":"COCRG, Cardiology Oncology Research Collaborative Group (CORCG), Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria"},{"name":"Department of Cardiology, Mustapha University Hospital Center Algiers, Algiers, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadera","family":"Methia","sequence":"additional","affiliation":[{"name":"COCRG, Cardiology Oncology Research Collaborative Group (CORCG), Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria"},{"name":"Department of Cardiology, Mustapha University Hospital Center Algiers, Algiers, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Latreche","sequence":"additional","affiliation":[{"name":"COCRG, Cardiology Oncology Research Collaborative Group (CORCG), Faculty of Medicine, Benyoucef 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