{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:43:10Z","timestamp":1789501390057,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Neutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p> We investigated whether the circulating neutrophil extracellular traps markers, double-stranded DNA and myeloperoxidase-DNA were associated with clinical outcome and hypercoagulability in patients with stable coronary artery disease. Patients with angiographically verified stable coronary artery disease ( n\u2009=\u20091001) were included. Follow-up was 2 years, recording 106 clinical endpoints (unstable angina, non-haemorrhagic stroke, myocardial infarction or death). Serum collected at baseline was used to determine double-stranded DNA and myeloperoxidase-DNA levels. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The neutrophil extracellular traps markers were weakly intercorrelated ( r\u2009=\u20090.103, P\u2009=\u20090.001). Patients with the highest quartile of double-stranded DNA had weakly but significantly elevated hypercoagulability markers (prothrombin fragment 1+2, D-dimer, free and total tissue factor pathway inhibitor ( P\u2009&lt;\u20090.001 for all)). Men, smokers, patients with metabolic syndrome and patients with a previous myocardial infarction had significantly elevated double-stranded DNA levels ( P\u2009\u2264\u20090.002 for all). Significantly higher double-stranded DNA levels were observed in the group experiencing a clinical endpoint compared to the group without ( P\u2009=\u20090.019). When categorising double-stranded DNA into quartiles, a distinct cut-off between the lowest and upper three quartiles was observed. Adjusting for relevant covariates, patients in the upper three quartiles had an odds ratio of 2.01 (95% confidence interval 1.12, 3.58, P\u2009=\u20090.019) for experiencing a clinical endpoint. Myeloperoxidase-DNA was not significantly associated with clinical outcome or hypercoagulability. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Double-stranded DNA levels were significantly related to adverse clinical outcome after 2 years, but only weakly associated with hypercoagulability. These observations suggest that the detrimental effects of neutrophil extracellular traps in coronary artery disease might extend beyond those related to hypercoagulability. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487318760618","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T12:10:01Z","timestamp":1519387801000},"page":"762-769","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Miriam Sj\u00e5stad","family":"Langseth","sequence":"first","affiliation":[{"name":"Center for Clinical Heart Research, Oslo University Hospital Ullev\u00e5l, Norway"},{"name":"Faculty of Medicine, University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine 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