{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:19:42Z","timestamp":1789067982741,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This cross-sectional observational study was conducted in 452 centres (August 2015\u2212August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients ( n\u2009=\u20099049) treated for \u22653 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The mean\u00b1SD age was 60.2\u2009\u00b1\u200911.7 years, 55.0% of patients were men and the mean\u2009\u00b1\u2009SD LDL-C value on LLT was 2.6\u2009\u00b1\u20091.3\u2009mmol\/L (101.0\u2009\u00b1\u200949.2\u2009mg\/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and\/or more intensive LLTs. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487318777079","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T12:42:17Z","timestamp":1526560937000},"page":"1087-1094","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":104,"title":["Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)"],"prefix":"10.1093","volume":"25","author":[{"given":"Nicolas","family":"Danchin","sequence":"first","affiliation":[{"name":"Department of Cardiology, European Hospital Georges-Pompidou, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Almahmeed","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, United 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