{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T16:48:41Z","timestamp":1780159721713,"version":"3.54.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p> In this observational study, we compared the effect of lipoprotein apheresis and evolocumab or alirocumab on levels of lipoprotein cholesterol, triglycerides and inflammatory markers (C reactive protein and interleukin 6) in cardiovascular patients ( n\u2009=\u20099). Patients were monitored during the last year of lipoprotein apheresis followed by six months of treatment with proprotein convertase subtilisin\/kexin type 9 inhibitors. The biochemical parameters were determined pre- and post- every apheresis procedure for 12 months and then after one, three and six months of treatment with evolocumab (140\u2009mg every two weeks [Q2W]) or alirocumab (75\u2009mg or 150\u2009mg every two weeks [Q2W]). Lipoprotein apheresis significantly reduced low-density lipoprotein cholesterol levels from 138\u2009\u00b1\u200932\u2009mg\/dl to 46\u2009\u00b1\u200916\u2009mg\/dl ( p\u2009&lt;\u20090.001), with an inter-apheresis level of 114\u2009\u00b1\u200926\u2009mg\/dl. Lipoprotein(a) was also reduced from a median of 42\u2009mg\/dl to 17\u2009mg\/dl ( p\u2009&lt;\u20090.01). Upon anti-proprotein convertase subtilisin\/kexin type 9 therapy, low-density lipoprotein cholesterol levels were similar to post-apheresis (59\u2009\u00b1\u200925, 41\u2009\u00b1\u200922 and 42\u2009\u00b1\u200921mg\/dl at one, three and six months, respectively) as well as those of lipoprotein(a) (18\u2009mg\/dl). However, an opposite effect was observed on high-density lipoprotein cholesterol levels: \u201316.0% from pre- to post-apheresis and +34.0% between pre-apheresis and proprotein convertase subtilisin\/kexin type 9 inhibitors. Apheresis significantly reduced high-sensitivity C-reactive protein levels (1.5\u2009\u00b1\u20091.2\u2009mg\/l pre-apheresis to 0.6\u2009\u00b1\u20090.6\u2009mg\/l post-apheresis), while no changes were found upon proprotein convertase subtilisin\/kexin type 9\u2009mAbs administration. In conclusion, our study demonstrated that, by switching from lipoprotein apheresis to anti-proprotein convertase subtilisin\/kexin type 9 therapies, patients reached similar low-density lipoprotein cholesterol and lipoprotein(a) levels, increased those of high-density lipoprotein cholesterol, and showed no changes on high-sensitivity C-reactive protein. <\/jats:p>","DOI":"10.1177\/2047487318792626","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T14:15:10Z","timestamp":1532960110000},"page":"1843-1851","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["From lipoprotein apheresis to proprotein convertase subtilisin\/kexin type 9 inhibitors: Impact on low-density lipoprotein cholesterol and C-reactive protein levels in cardiovascular disease patients"],"prefix":"10.1093","volume":"25","author":[{"given":"Maria G","family":"Zenti","sequence":"first","affiliation":[{"name":"Divisione di Endocrinologia, Diabetologia e Metabolismo, Universit\u00e0 degli Studi di Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Altomari","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinologia, Diabetologia e Metabolismo, Universit\u00e0 degli Studi di Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G","family":"Lupo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 degli Studi di Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Botta","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, 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