{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:59:12Z","timestamp":1778705952146,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Full secondary prevention medication regimen is often under-prescribed after acute myocardial infarction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p> The purpose of this study was to analyse the relationship between prescription of appropriate secondary prevention treatment at discharge and long-term clinical outcomes according to risk level defined by the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Secondary Prevention (TRS-2P) after acute myocardial infarction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We used data from the 2010 French Registry of Acute ST-Elevation or non-ST-elevation Myocardial Infarction (FAST-MI) registry, including 4169 consecutive acute myocardial infarction patients admitted to cardiac intensive care units in France. Level of risk was stratified in three groups using the TRS-2P score: group 1 (low-risk; TRS-2P=0\/1); group 2 (intermediate-risk; TRS-2P=2); and group 3 (high-risk; TRS-2P\u22653). Appropriate secondary prevention treatment was defined according to the latest guidelines (dual antiplatelet therapy and moderate\/high dose statins for all; new-P2Y12 inhibitors, angiotensin-converting-enzyme inhibitor\/angiotensin-receptor-blockers and beta-blockers as indicated). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Prevalence of groups 1, 2 and 3 was 46%, 25% and 29% respectively. Appropriate secondary prevention treatment at discharge was used in 39.5%, 37% and 28% of each group, respectively. After multivariate adjustment, evidence-based treatments at discharge were associated with lower rates of major adverse cardiovascular events (death, re-myocardial infarction or stroke) at five years especially in high-risk patients: hazard ratio\u2009=\u20090.82 (95% confidence interval: 0.59\u20131.12, p\u2009=\u20090.21) in group 1, 0.74 (0.54\u20131.01; p\u2009=\u20090.06) in group 2, and 0.64 (0.52\u20130.79, p\u2009&lt;\u20090.001) in group 3. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Use of appropriate secondary prevention treatment at discharge was inversely correlated with patient risk. The increased hazard related to lack of prescription of recommended medications was much larger in high-risk patients. Specific efforts should be directed at better prescription of recommended treatment, particularly in high-risk patients. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487318808638","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T05:31:52Z","timestamp":1540445512000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Appropriate secondary prevention and clinical outcomes after acute myocardial infarction according to atherothrombotic risk stratification: The FAST-MI 2010 registry"],"prefix":"10.1093","volume":"26","author":[{"given":"Victoria","family":"Tea","sequence":"first","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Europ\u00e9en Georges Pompidou (HEGP), France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bonaca","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Cayla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nimes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Angoulvant","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU Tours & Tours University, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Ferri\u00e8res","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rangueil Hospital, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Schiele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Jean Minjoz, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabassome","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Clinical 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