{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:20:41Z","timestamp":1781839241573,"version":"3.54.5"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":442,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-based heart failure management in a large registry at heart failure outpatient clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>We studied 8351 heart failure with reduced ejection fraction patients at 34 Dutch outpatient clinics between 2013 and 2016. The mean age was 72.3\u2009\u00b1\u200911.8 years and we divided age into three categories: less than 60 years (13.9%); 60\u201374 years (36.0%); and 75 years and over (50.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elderly heart failure with reduced ejection fraction patients (\u226575 years) received significantly fewer beta-blockers (77.8% vs. 84.2%), renin\u2013angiotensin system inhibitors (75.2% vs. 89.7%), mineralocorticoid receptor antagonists (50.6% vs. 59.6%) and ivabradine (2.9% vs. 9.3%), but significantly more diuretics (88.1% vs. 72.6%) compared to patients aged less than 60 years (Pfor all trends\u2009&amp;lt;\u20090.01). Moreover, the prescribed target dosages were significantly lower in elderly patients. Also, implantable cardioverter defibrillator (18.9% vs. 44.1%) and cardiac resynchronisation therapy device (14.6% vs. 16.7%) implantation rates were significantly lower in elderly patients. A similar trend in drug prescription was observed in patients with heart failure with mid-range ejection fraction as in heart failure with reduced ejection fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With increasing age, heart failure with reduced ejection fraction patients less often received guideline-recommended medication prescriptions and also in a lower dosage. In addition, a lower percentage of implantable cardioverter defibrillator and cardiac resynchronisation therapy device implantation in elderly patients was observed.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487319835042","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T21:34:16Z","timestamp":1552512856000},"page":"1399-1407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Age differences in contemporary treatment of patients with chronic heart failure and reduced ejection fraction"],"prefix":"10.1093","volume":"26","author":[{"given":"Jesse F","family":"Veenis","sequence":"first","affiliation":[{"name":"Department of Cardiology , Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Maastricht University Medical Center, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard CM","family":"Linssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Hospital Group Twente, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Geerlings","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Jans Gasthuis, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco WF","family":"Van Gent","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Albert Schweitzer Ziekenhuis, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Admiraal De Ruyter Ziekenhuis, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane","family":"Oosterom","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Waterlandziekenhuis, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno HM","family":"Moons","sequence":"additional","affiliation":[{"name":"Department of Cardiology , MC Slotervaart, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno W","family":"Hoes","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care , University Medical Center Utrecht and Utrecht University, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper J","family":"Brugts","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CHECK-HF investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"2023040618235050800_","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ejhf.813","article-title":"Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2023040618235050800_","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. 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