{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:53:48Z","timestamp":1771559628248,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The recent American College of Cardiology\/American Heart Association guidelines for high blood pressure lowered the hypertension criteria from systolic\/diastolic blood pressure (SBP\/DBP) of 140\/90\u2009mmHg or greater to 130\/80\u2009mmHg or greater, while the potential impact of the change on Chinese adults remains unclear. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p> A pooled prospective cohort analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Included were 154,407 Chinese adults from three prospective cohorts, which measured blood pressure at baseline and follow-up visits, and tracked death events by linkages to medical insurance system or vital statistics registries. Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> During a total follow-up of 1,718,089 person-years, 14,692 deaths were documented including 5086 cardiovascular deaths (1277 ischaemic heart disease and 2509 cerebrovascular disease deaths). Compared to normal blood pressure (SBP\/DBP\u2009&lt;\u2009120\/80\u2009mmHg), newly defined stage 1 hypertension (SBP\/DBP 130\u2013139\/80\u201389\u2009mmHg) was associated with increased cardiovascular mortality (HR 1.40, 95% CI 1.16\u20131.69; HR 1.36, 95% CI 1.12\u20131.65 for ischaemic heart disease mortality; HR 1.53, 95% CI 1.18\u20132.00 for cerebrovascular mortality), but not with all-cause mortality (HR 1.04, 95% CI 0.89\u20131.21). Stage 2 hypertension (SBP\/DBP\u2009\u2265\u2009140\/90\u2009mmHg) showed significant associations with cardiovascular disease and all-cause mortality, while elevated blood pressure (SBP 120\u2013129\u2009mmHg and DBP\u2009&lt;\u200980\u2009mmHg) showed null associations. The associations were stronger in adults younger than 65 years and adults without pre-existing cardiovascular disease compared with their counterparts ( P for heterogeneity\u2009&lt;\u20090.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The newly defined stage 1 hypertension is associated with an increased risk of cardiovascular disease mortality in the Chinese population, particularly among younger adults and those without a history of cardiovascular disease. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487319862066","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T04:38:16Z","timestamp":1562733496000},"page":"345-354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Associations of blood pressure categories defined by 2017 ACC\/AHA guidelines with mortality in China: Pooled results from three prospective cohorts"],"prefix":"10.1093","volume":"27","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Huazhong University of Science and Technology, China"},{"name":"Department of Health Care, The First Affiliated Hospital with Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Jeong","family":"Yang","sequence":"additional","affiliation":[{"name":"Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiwei","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Huazhong University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong-Fei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Huazhong University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Huazhong University of Science and Technology, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), Huazhong University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Huazhong University of Science and Technology, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), Huazhong University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Jiaotong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Jiaotong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Jiaotong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Vanderbilt Epidemiology 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Huazhong University of Science and Technology, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), Huazhong University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"bibr1-2047487319862066","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"bibr2-2047487319862066","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001528"},{"key":"bibr3-2047487319862066","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"bibr4-2047487319862066","first-page":"e13","volume":"71","author":"Whelton 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