{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:35Z","timestamp":1789609235674,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate the effect of microsomal triglyceride transfer protein inhibitor (lomitapide) in patients with homozygous familial hypercholesterolaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In 12 homozygous familial hypercholesterolaemia patients treated with lipid-lowering drugs\u2009\u00b1\u2009biweekly lipoprotein apheresis sessions (nine patients), daily lomitapide was added. The lipid profile (total cholesterol, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol) before and after lomitapide treatment was evaluated. The follow-up period with lomitapide treatment was 3\u201324 months (13.8\u2009\u00b1\u20097.9). The median baseline low-density lipoprotein cholesterol level was 900\u2009mg\/dl (348\u20131070), after lipid-lowering drugs therapy was 383.5\u2009mg\/dl (214\u2013866) and after lipid-lowering drugs\u2009+\u2009time-averaged level was 288\u2009mg\/dl (183.7\u2013716.6). The addition of lomitapide lowered low-density lipoprotein cholesterol levels further by 56.8% compared to lipid-lowering drugs alone (mean reduction 262, 95% confidence interval (105.5\u2013418.7), p\u2009=\u20090.005) and by 54% (mean reduction 182.9, 95% confidence interval (\u2212342\u2009\u2013\u2009\u221223), p\u2009=\u20090.031) comparing to lipid-lowering drugs\u2009+\u2009lipoprotein apheresis (time-averaged level). The time-averaged level of low-density lipoprotein cholesterol in lipid-lowering drugs\u2009+\u2009lipoprotein apheresis patients compared with lipid-lowering drugs\u2009+\u2009lomitapide was 54% in favour of lomitapide ( p\u2009=\u20090.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with lomitapide in homozygous familial hypercholesterolaemia patients has a beneficial effect with a constant decrease of low-density lipoprotein cholesterol by 57% compared with classical lipid-lowering therapy and by 54% compared with classical lipid-lowering therapy and time-averaged level of low-density lipoprotein cholesterol.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487319870007","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T16:22:55Z","timestamp":1565626975000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Microsomal triglyceride transfer protein inhibitor (lomitapide) efficacy in the treatment of patients with homozygous familial hypercholesterolaemia"],"prefix":"10.1093","volume":"27","author":[{"given":"Genovefa","family":"Kolovou","sequence":"first","affiliation":[{"name":"Department of Cardiology, Onassis Cardiac Surgery Center, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Diakoumakou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Onassis Cardiac Surgery Center, 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