{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:41:09Z","timestamp":1791229269260,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p> Prescribed exercise is effective in adults with coronary heart disease (CHD), chronic heart failure (CHF), intermittent claudication, body mass index (BMI) \u226525\u2009kg\/m<jats:sup>2<\/jats:sup>, hypertension or type 2 diabetes mellitus (T2DM), but the evidence for its cost-effectiveness is limited, shows large variations and is partly contradictory. Using World Health Organization and American Heart Association\/American College of Cardiology value for money thresholds, we report the cost-effectiveness of exercise therapy, exercise training and exercise-based cardiac rehabilitation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Electronic databases were searched for incremental cost-effectiveness and incremental cost\u2013utility ratios and\/or the probability of cost-effectiveness of exercise prescribed as therapy in economic evaluations conducted alongside randomized controlled trials (RCTs) published between 1 July 2008 and 28 October 2018. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of 19 incremental cost\u2013utility ratios reported in 15 RCTs in patients with CHD, CHF, intermittent claudication or BMI \u226525\u2009kg\/m<jats:sup>2<\/jats:sup>, 63% met both value for money thresholds as \u2018highly cost-effective\u2019 or \u2018high value\u2019, with 26% \u2018not cost-effective\u2019 or of \u2018low value\u2019. The probability of intervention cost-effectiveness ranged from 23 to 100%, probably due to the different populations, interventions and comparators reported in the individual RCTs. Confirmation with the Consolidated Health Economic Evaluation Reporting checklist varied widely across the included studies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The findings of this review support the cost-effectiveness of exercise therapy in patients with CHD, CHF, BMI \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> or intermittent claudication, but, with concerns about reporting standards, need further confirmation. No eligible economic evaluation based on RCTs was identified in patients with hypertension or T2DM. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487319881839","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T13:36:22Z","timestamp":1572096982000},"page":"1045-1055","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Cost-effectiveness of exercise therapy in patients with coronary heart disease, chronic heart failure and associated risk factors: A systematic review of economic evaluations of randomized clinical trials"],"prefix":"10.1093","volume":"27","author":[{"given":"Neil","family":"Oldridge","sequence":"first","affiliation":[{"name":"College of Health Sciences, University of Wisconsin-Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Health and Well 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