{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:53:03Z","timestamp":1792025583505,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Improvement in exercise capacity is a main goal of cardiac rehabilitation but the effects are often lost at long-term follow-up and thus also the benefits on prognosis. We assessed whether improvement in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      during a cardiac rehabilitation programme predicts long-term prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective analysis of 1561 cardiac patients completing cardiac rehabilitation in 2011\u20132017 in Copenhagen. Mean age was 63.6 (11) years, 74% were male and 84% had coronary artery disease, 6% chronic heart failure and 10% heart valve replacement. The association between baseline VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and improvement after cardiac rehabilitation and being readmitted for cardiovascular disease and\/or all-cause mortality was assessed with three different analyses: Cox regression for the combined outcome, for all-cause mortality and a multi-state model. During a median follow-up of 2.3 years, 167 readmissions for cardiovascular disease and 77 deaths occurred. In adjusted Cox regression there was a non-linear decreasing risk of the combined outcome with higher baseline VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and with improvement of VO\n                      <jats:sub>2peak<\/jats:sub>\n                      after cardiac rehabilitation. A similar linear association was seen for all-cause mortality. Applying the multi-state model, baseline VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and change in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      were associated with risk of a cardiovascular disease readmission and with all-cause mortality but not with mortality in those having an intermediate readmission for cardiovascular disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      VO\n                      <jats:sub>2peak<\/jats:sub>\n                      as well as change in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      were highly predictive of future risk of readmissions for cardiovascular disease and all-cause mortality. The predictive value did not extend beyond the next admission for a cardiovascular event.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2047487319887835","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T02:20:05Z","timestamp":1574216405000},"page":"811-819","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":95,"title":["Improvement in VO\n                    <sub>2peak<\/sub>\n                    predicts readmissions for cardiovascular disease and mortality in patients undergoing cardiac rehabilitation"],"prefix":"10.1093","volume":"27","author":[{"given":"Nicolai","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Bispebjerg Frederiksberg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cadarso-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Department of Statistics, Mathematical Analysis, and Optimization, Universidade de Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lado-Baleato","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Department of Statistics, Mathematical Analysis, and Optimization, Universidade de Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"D\u00edaz-Louzao","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Department of Statistics, Mathematical Analysis, and Optimization, Universidade de Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos P","family":"Gil","sequence":"additional","affiliation":[{"name":"Cardiology and Coronary Care Department Hospital Cl\u00ednico Universitario, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Reeh","sequence":"additional","affiliation":[{"name":"Bispebjerg Frederiksberg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Rasmusen","sequence":"additional","affiliation":[{"name":"Bispebjerg Frederiksberg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Prescott","sequence":"additional","affiliation":[{"name":"Bispebjerg Frederiksberg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"bibr1-2047487319887835","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.07.011"},{"key":"bibr2-2047487319887835","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.681"},{"key":"bibr3-2047487319887835","first-page":"CD001800","volume":"7","author":"Heran BS","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr4-2047487319887835","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.044"},{"key":"bibr5-2047487319887835","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318798924"},{"key":"bibr6-2047487319887835","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319854141"},{"key":"bibr7-2047487319887835","volume":"53","author":"Mitchell BL","year":"2018","journal-title":"Br J Sports 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