{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:14Z","timestamp":1787019374151,"version":"build-2736575974"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Stanley Steyer Institute for Cancer Epidemiology and Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with coronary heart disease are considered susceptible to traffic-related air pollution exposure. Yet, cohort-based evidence on whether preexisting coronary heart disease modifies the association of traffic-related air pollution with health outcomes is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Using data of four Israeli cohorts, we compared associations of traffic-related air pollution with mortality and cancer between coronary heart disease patients and matched controls from the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects hospitalized with acute coronary syndrome from two patient cohorts (inception years: 1992\u20131993 and 2006\u20132014) were age- and sex-matched to coronary heart disease-free participants of two cycles of the Israeli National Health and Nutrition Surveys (inception years: 1999\u20132001 and 2005\u20132006). Ambient concentrations of nitrogen oxides at the residential place served as a proxy for traffic-related air pollution exposure across all cohorts, based on a high-resolution national land use regression model (50 m). Data on all-cause mortality (last update: 2018) and cancer incidence (last update: 2016) were retrieved from national registries. Cox-derived stratum-specific hazard ratios with 95% confidence intervals were calculated, adjusted for harmonized covariates across cohorts, including age, sex, ethnicity, neighborhood socioeconomic status, smoking, diabetes, hypertension, prior stroke and prior malignancy (the latter only in the mortality analysis). Effect-modification was examined by testing nitrogen oxides-by-coronary heart disease interaction term in the entire matched cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort (mean (standard deviation) age 61.5 (14) years; 44% women) included 2393 matched pairs, among them 2040 were cancer-free at baseline. During a median (25th\u201375th percentiles) follow-up of 13 (10\u201319) and 11 (7\u201317) years, 1458 deaths and 536 new cancer cases were identified, respectively. In multivariable-adjusted models, a 10-parts per billion nitrogen oxides increment was positively associated with all-cause mortality among coronary heart disease patients (hazard ratio\u2009=\u20091.13, 95% confidence interval 1.05\u20131.22), but not among controls (hazard ratio\u2009=\u20091.00, 0.93\u20131.08) (pinteraction\u2009=\u20090.003). A similar pattern was seen for all-cancer incidence (hazard ratioCHD\u2009=\u20091.19 (1.03\u20131.37), hazard ratioCHD-Free\u2009=\u20090.93 (0.84\u20131.04) (pinteraction\u2009=\u20090.01)). Associations were robust to multiple sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coronary heart disease patients might be at increased risk for traffic-related air pollution-associated mortality and cancer, irrespective of their age and sex. Patients and clinicians should be more aware of the adverse health effects on coronary heart disease patients of chronic exposure to vehicle emissions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2047487320921987","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:43:38Z","timestamp":1589013818000},"page":"1475-1486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Preexisting coronary heart disease and susceptibility to long-term effects of traffic-related air pollution: A matched cohort analysis"],"prefix":"10.1093","volume":"28","author":[{"given":"Gali","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Tel Aviv University, Israel"},{"name":"Stanley Steyer Institute for Cancer Epidemiology and Research, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lital","family":"Keinan-Boker","sequence":"additional","affiliation":[{"name":"Israel Center for Disease Control, Israel Ministry of Health, Israel"},{"name":"School of Public Health, University of Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00a0","family":"Yuval","sequence":"additional","affiliation":[{"name":"Technion Center of Excellence in Exposure Science and Environmental Health, Technion Israel Institute of Technology, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Levy","sequence":"additional","affiliation":[{"name":"Technion Center of Excellence in Exposure Science and Environmental Health, Technion Israel Institute of Technology, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Chen","sequence":"additional","affiliation":[{"name":"Technion Center of Excellence in Exposure Science and Environmental Health, Technion Israel Institute of Technology, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakefet","family":"Shafran-Nathan","sequence":"additional","affiliation":[{"name":"Technion Center of Excellence in Exposure Science and Environmental Health, Technion Israel Institute of Technology, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Geography, Hebrew University of Jerusalem, Israel"},{"name":"Remote Sensing Research Centre, School of Earth and Environmental Sciences, The University of Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Shimony","sequence":"additional","affiliation":[{"name":"Israel Center for Disease Control, Israel Ministry of Health, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Witberg","sequence":"additional","affiliation":[{"name":"Remote Sensing Research Centre, School of Earth and Environmental Sciences, The University of Queensland, Australia"},{"name":"Department of Cardiology, Rabin Medical Center (Beilinson and Hasharon Hospitals), Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Bental","sequence":"additional","affiliation":[{"name":"Remote Sensing Research Centre, School of Earth and Environmental Sciences, The University of Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Shohat","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Broday","sequence":"additional","affiliation":[{"name":"Technion Center of Excellence in Exposure Science and Environmental Health, Technion Israel Institute of Technology, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Remote Sensing Research Centre, School of Earth and Environmental Sciences, The University of Queensland, Australia"},{"name":"Deptartment of Cardiovascular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yariv","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Tel Aviv University, Israel"},{"name":"Stanley Steyer Institute for Cancer Epidemiology and Research, Tel Aviv University, 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