{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:15:47Z","timestamp":1778868947735,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to determine the relationships of pericardial adipose tissue and visceral adipose tissue volume with added sugar and sugar-sweetened beverage intakes. We hypothesized that both added sugar and sugar-sweetened beverages were positively associated with pericardial adipose tissue and visceral adipose tissue volumes in black and white men and women enrolled in the prospective Coronary Artery Risk Development in Young Adults study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Dietary intake was assessed by diet history at baseline, year 7 and year 20 examinations in 3070 participants aged 18-30 and generally healthy at baseline. After 25 years follow-up, participants underwent a computed tomography scan of chest and abdomen; the computed tomography scans were read, and pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes were calculated. Quintiles were created for the average of baseline, year 7 and year 20 added sugar and for the average of sugar-sweetened beverages. General linear regression analysis evaluated the associations of pericardial adipose tissue and visceral adipose tissue volumes across quintiles of added sugar and across quintiles of sugar-sweetened beverage intakes adjusted for potential confounding factors. In a multivariable model, pericardial adipose tissue volume was higher across increasing quintiles of added sugar and sugar-sweetened beverage intakes (ptrend\u2009=\u20090.001 and ptrend\u2009&amp;lt;\u20090.001, respectively). A similar relation was observed for visceral adipose tissue (ptrend\u2009&amp;lt;\u20090.001 for both added sugar and sugar-sweetened beverages).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long-term intakes of added sugar and sugar-sweetened beverages were associated with higher pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes. Because these ectopic fat depots are associated with greater risk of disease incidence, these findings support limiting intakes of added sugar and sugar-sweetened beverages.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2047487320931303","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T23:06:05Z","timestamp":1593385565000},"page":"2016-2023","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Added sugar intake is associated with pericardial adipose tissue volume"],"prefix":"10.1093","volume":"27","author":[{"given":"So-Yun","family":"Yi","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn M","family":"Steffen","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"David","family":"R Jacobs","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Duprez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Shikany","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Harnack","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"J Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2021020116554928400_bibr1-2047487320931303","author":"European Commission Health Promotion and Disease Prevention Knowledge Gateway. 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