{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:59:13Z","timestamp":1782233953964,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Under the term degenerative mitral valve prolapse different pathophysiological and clinical entities coexist in a spectrum ranging from Barlow\u2019s disease to fibroelastic deficiency, and represent the most common cause of mitral regurgitation in the general population and in athletes. Carrying a mitral valve prolapse is usually considered a benign condition for athletes, but recently the scientific literature has focused on the malignant, thus rare, arrhythmic mitral valve prolapse and its dramatic association with sudden cardiac death, so that specific features should be considered a red flag and prompt additional exams before clear for competition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>As the athlete\u2019s heart is morphologically accompanied by remodelling and dilatation of the cardiac chambers induced by exercise, it may be challenging to differentiate the degree of left ventricular and atrial dilation induced by significant mitral regurgitation from physiological remodelling, especially in endurance athletes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This how-to article provides clinical and useful data to manage athletes with mitral valve prolapse and to distinguish high-risk athletes carrying the features of arrhythmic mitral valve prolapse.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2047487320941646","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T04:13:45Z","timestamp":1596168825000},"page":"1110-1117","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["How to manage an athlete with mitral valve prolapse"],"prefix":"10.1093","volume":"28","author":[{"given":"Elena","family":"Cavarretta","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy"},{"name":"Mediterranea Cardiocentro, Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy"},{"name":"Mediterranea Cardiocentro, Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Versaci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Santa Maria Goretti Hospital, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Frati","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy"},{"name":"IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Policlinico Casilino, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2021082320504386100_zwaa444-B1","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1161\/CIRCULATIONAHA.113.006702","article-title":"Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis","volume":"129","author":"Delling","year":"2014","journal-title":"Circulation"},{"key":"2021082320504386100_zwaa444-B2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5223(19)39144-5","article-title":"Cardiac valve surgery\u2013the \u201cFrench correction\u201d","volume":"86","author":"Carpentier","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021082320504386100_zwaa444-B3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1053\/j.semtcvs.2007.04.002","article-title":"Etiologic classification of degenerative mitral valve disease: Barlow\u2019s disease and fibroelastic deficiency","volume":"19","author":"Anyanwu","year":"2007","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"2021082320504386100_zwaa444-B4","doi-asserted-by":"crossref","first-page":"342984","DOI":"10.1155\/2015\/342984","article-title":"Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution","volume":"2015","author":"Cottignoli","year":"2015","journal-title":"Pathol Res Intl"},{"key":"2021082320504386100_zwaa444-B5","first-page":"774","article-title":"Accessory mitral valve tissue causing left ventricular outflow tract obstruction: case reports and literature review","volume":"10","author":"Prifti","year":"2001","journal-title":"J Heart Valve Dis"},{"key":"2021082320504386100_zwaa444-B6","first-page":"548","article-title":"The new 2010 Ghent criteria for the indication to surgical treatment of patients affected by Marfan syndrome. 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