{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T18:53:22Z","timestamp":1667933602944},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2_suppl","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Metabolic Exercise combined with Cardiac and Kidney Indexes [MECKI) score is a validated prognostic score for heart failure with reduced ejection fraction which combines commonly available clinical and metabolic parameters with two cardiopulmonary exercise test derived prognostic measurements. It has been validated to predict prognosis and to aid clinical decision making and it has been shown to be superior in predicting mortality compared with other commonly used prognostic scores for heart failure. In the future it would be valuable to establish whether the score holds true also in other settings, and in particular in under-represented groups \u2013 the elderly, women, and people of different ethnic backgrounds \u2013 and in other heart failure syndromes. In future it may be extended to assess its value in the presence of a range of co-morbidities such as chronic obstructive pulmonary disease, pulmonary hypertension and frailty and cachexia as well as in other conditions such as hypertrophic cardiomyopathy, amyloid, asymptomatic left ventricular dysfunction and hypertension. It may also be a candidate end-point for adaptive trials designed to prove an improvement in the MECKI score as an approvable interim end-point whilst larger mortality and morbidity trials are still underway.<\/jats:p>","DOI":"10.1177\/2047487320962983","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T09:23:26Z","timestamp":1606382606000},"page":"72-75","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Future developments in the MECKI score initiative"],"prefix":"10.1093","volume":"27","author":[{"given":"Andrew JS","family":"Coats","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2021020116503909000_bibr1-2047487320962983","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardfail.2020.04.021","article-title":"Cardiovascular death risk in recovered mid-range ejection fraction heart failure: Insights from cardiopulmonary exercise test.","author":"Magri","year":"2020","journal-title":"J Card Fail"},{"key":"2021020116503909000_bibr2-2047487320962983","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1161\/01.CIR.95.12.2660","article-title":"Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation","volume":"95","author":"Aaronson","year":"1997","journal-title":"Circulation"},{"key":"2021020116503909000_bibr3-2047487320962983","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/CIRCULATIONAHA.105.584102","article-title":"The Seattle Heart Failure Model: Prediction of survival in heart failure","volume":"113","author":"Levy","year":"2006","journal-title":"Circulation"},{"key":"2021020116503909000_bibr4-2047487320962983","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ejhf.989","article-title":"Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction: A long-term comparison","volume":"20","author":"Agostoni","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2021020116503909000_bibr5-2047487320962983","article-title":"Comparison of MAGGIC and MECKI risk scores to predict mortality after cardiac rehabilitation among Dutch heart failure patients","author":"Kouwert","journal-title":"Eur J Prev Cardiol"},{"key":"2021020116503909000_bibr6-2047487320962983","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.ijcard.2012.06.113","article-title":"Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: A multiparametric approach to heart failure prognosis","volume":"167","author":"Agostoni","year":"2013","journal-title":"Int J Cardiol"},{"key":"2021020116503909000_bibr7-2047487320962983","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.ijcard.2015.11.075","article-title":"The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score and prognosis in heart failure. 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