{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:35:51Z","timestamp":1777545351254,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Platelet adhesion, activation, and aggregation are central to the propagation of coronary thrombosis following rupture, fissure, or erosion of an atherosclerotic plaque. This chain of deleterious events underlies the pathophysiological process leading to an acute coronary syndrome. Therefore, oral antiplatelet therapy has become the cornerstone of therapy for the management of acute coronary syndrome and the prevention of ischemic complications associated with percutaneous coronary intervention. Landmark trials have established aspirin, and the addition of clopidogrel to aspirin, as key therapeutic agents in the context of acute coronary syndrome and percutaneous coronary intervention. Dual antiplatelet therapy has been the guideline-mandated standard of care in acute coronary syndrome and percutaneous coronary intervention. Despite the proven efficacy of dual antiplatelet therapy, adverse ischemic events continue to occur and this has stimulated the development of novel, more potent antiplatelet agents. We focus this state-of-the-art review on the most recent advances in oral antiplatelet therapy, treading the tightrope of potency versus bleeding risk, the quest to determine the optimal duration of dual antiplatelet therapy and future of personalized antiplatelet therapy.<\/jats:p>","DOI":"10.1177\/2048004016652514","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T23:43:57Z","timestamp":1464824637000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["State of the art: Oral antiplatelet therapy"],"prefix":"10.1177","volume":"5","author":[{"given":"Paul A","family":"Gurbel","sequence":"first","affiliation":[{"name":"Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aung","family":"Myat","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Coventry, University Hospitals of Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Kubica","sequence":"additional","affiliation":[{"name":"Department of Cardiology, and Internal Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya S","family":"Tantry","sequence":"additional","affiliation":[{"name":"Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"bibr1-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303412"},{"key":"bibr2-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2293"},{"key":"bibr3-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.05.001"},{"key":"bibr4-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.049"},{"key":"bibr5-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60503-1"},{"key":"bibr6-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61088-4"},{"key":"bibr7-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"bibr8-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.04.001"},{"key":"bibr9-2048004016652514","doi-asserted-by":"publisher","DOI":"10.2217\/fca.15.60"},{"key":"bibr10-2048004016652514","doi-asserted-by":"crossref","unstructured":"Price MJ, Berger PB, Teirstein PS, et\u00a0al. GRAVITAS Investigators. Standard- vs. high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial.\n                      JAMA\n                      201; 305: 1097\u2013105.","DOI":"10.1001\/jama.2011.290"},{"key":"bibr11-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209979"},{"key":"bibr12-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.101"},{"key":"bibr13-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.704909"},{"key":"bibr14-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"bibr15-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205512"},{"key":"bibr16-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308075"},{"key":"bibr17-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"bibr18-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500857"},{"key":"bibr19-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"bibr20-2048004016652514","first-page":"400","volume":"37","author":"Magnani G","year":"2016","journal-title":"Eur Heart J"},{"key":"bibr21-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60612-7"},{"key":"bibr22-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"bibr23-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.047431"},{"key":"bibr24-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1109447"},{"key":"bibr25-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200933"},{"key":"bibr26-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61269-0"},{"key":"bibr27-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"bibr28-2048004016652514","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"bibr29-2048004016652514","doi-asserted-by":"crossref","unstructured":"Levine GN, O'Gara PT, Bates ER, et\u00a0al. 2015 ACC\/AHA\/SCAI focused update on primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction: an update of the 2011 ACCF\/AHA\/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.\n                      J Am Coll Cardiol\n                      2016; 67: 1235\u20131250.","DOI":"10.1016\/j.jacc.2015.10.005"}],"container-title":["JRSM Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2048004016652514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2048004016652514","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2048004016652514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:33:00Z","timestamp":1777397580000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2048004016652514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":29,"alternative-id":["10.1177\/2048004016652514"],"URL":"https:\/\/doi.org\/10.1177\/2048004016652514","relation":{},"ISSN":["2048-0040","2048-0040"],"issn-type":[{"value":"2048-0040","type":"print"},{"value":"2048-0040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"article-number":"2048004016652514"}}