{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:36:06Z","timestamp":1777545366115,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The renin-angiotensin-aldosterone system may be altered in patients with resistant hypertension. This study aimed to evaluate the relation between renin-angiotensin-aldosterone system activity and resistant hypertension in Cameroonian diabetes patients with resistant hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We carried out a case-control study including 19 diabetes patients with resistant hypertension and 19 diabetes patients with controlled hypertension matched to cases according to age, sex and duration of hypertension since diagnosis. After collection of data, fasting blood was collected for measurement of sodium, potassium, chloride, active renin and plasma aldosterone of which the aldosterone-renin ratio was derived to assess the activity of renin-angiotensin-aldosterone system. Then, each participant received 2000\u2009ml infusion of saline solution after which plasma aldosterone was re-assayed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Potassium levels were lower among cases compared to controls (mean: (4.10\u2009\u00b1\u20090.63\u2009mmol\/l vs. 4.47\u2009\u00b1\u20090.58\u2009mmol\/l), though nonsignificant (p\u2009=\u20090.065). Active renin, plasma aldosterone both before and after the dynamic test and aldosterone-renin ratio were comparable between cases and controls (all p values\u2009&gt;\u20090.05). Plasma aldosterone significantly decreased after the dynamic test in both groups (p\u2009&lt;\u20090.001), but no participant exhibited a post-test value&gt;280\u2009pmol\/l. We found a significant negative correlation between potassium ion and plasma aldosterone (\u03c1\u2009=\u2009\u22120.324; p\u2009=\u20090.047), the other correlations being weak and unsignificant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although this study failed to show an association between RH and primary hyperaldosteronism in our context, there was a hyperactivity of renin-angiotensin-aldosterone system. Moreover, this study confirms the importance of potassium dosage when screening the renin-angiotensin-aldosterone system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048004017695006","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T02:14:33Z","timestamp":1488334473000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism"],"prefix":"10.1177","volume":"6","author":[{"given":"Bertille Elodie","family":"Edinga-Melenge","sequence":"first","affiliation":[{"name":"Centre Pasteur of Cameroon, Yaound\u00e9, Cameroon"},{"name":"Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky J","family":"Ama Moor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jobert Richie N","family":"Nansseu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romance","family":"Nguetse Djoumessi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel K","family":"Mengnjo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Katte","sequence":"additional","affiliation":[{"name":"Biotechnology Centre, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Jacques N","family":"Noubiap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Sobngwi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, Yaound\u00e9, Cameroon"},{"name":"National Obesity Centre, Diabetes and Metabolic Diseases Unit, Yaound\u00e9 Central Hospital, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"bibr1-2048004017695006","unstructured":"World Health Organization.\n                      Global status report on non communicable diseases 2014: Attaining the nine global noncommunicable diseases targets: A shared responsibility\n                      . 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