{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:06Z","timestamp":1790630526245,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Irish Government","award":["Specific Grant to Establish"],"award-info":[{"award-number":["Specific Grant to Establish"]}]},{"name":"Irish Life PLC","award":["Specific Grant"],"award-info":[{"award-number":["Specific Grant"]}]},{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","award":["Special Grant"],"award-info":[{"award-number":["Special Grant"]}],"id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["Special Grant"],"award-info":[{"award-number":["Special Grant"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Orthostatic Hypotension (OH) is an abnormal drop in blood pressure (BP) that occurs following orthostatic challenge. OH is associated with increased risk of falls, cognitive impairment and death. White Matter Hyperintensities (WMH) on MR Brain are associated with vascular risk factors such as hypertension, diabetes and age. We examined whether extent White matter intensities were associated with presence of OH detected in a community dwelling population of older people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals from the MR sub-study of the Irish Longitudinal Study of Ageing underwent a 3 Tesla MR Brain scan to assess WMH severity (Schelten\u2019s Score). The scans were performed during the Wave 3 TILDA health assessment phase when the subjects also underwent assessment for OH with an active stand protocol. Data was analysed for association between WMH and vascular risks and orthostatic change in BP 10\u2009second intervals during the OH evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>440 subjects were investigated; median age 72\u2009years (65\u201392\u2009years) and 228 (51.5%) female. Range of Scheltens\u2019 Scores was 0\u201332. Mean score was 9.72 (SD 5.87). OH was detected in 68.4% (301). On linear regression, positive associations were found between Scheltens\u2019 Score and age, hypertension, prior history of stroke and TIA, and with OH at 30, 70, 90 and 100\u2009seconds following standing (p\u2009&lt;\u20090.05, O.R. 1.9\u20132.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WMD is associated with OH detected at multiple time points using active stand in community dwelling older subjects. Further research is necessary to evaluate the direction of this association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048004020954628","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:35:16Z","timestamp":1599179716000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Is there an association between orthostatic hypotension and cerebral white matter hyperintensities in older people? The Irish longitudinal study on ageing"],"prefix":"10.1177","volume":"9","author":[{"given":"Anne","family":"Buckley","sequence":"first","affiliation":[{"name":"The Irish Longitudinal Study of Ageing and Department of Medical Gerontology, Trinity College Dublin, University of Dublin, Dublin, Ireland"},{"name":"Centre for Advanced Medical Imaging, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Carey","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study of Ageing and Department of Medical Gerontology, Trinity College Dublin, University of Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Meaney","sequence":"additional","affiliation":[{"name":"Centre for Advanced Medical Imaging, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RoseAnne","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study of Ageing and Department of Medical Gerontology, Trinity College Dublin, University of Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-5751","authenticated-orcid":false,"given":"Joseph","family":"Harbison","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study of Ageing and Department of Medical Gerontology, Trinity College Dublin, University of Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"bibr1-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.3.652"},{"key":"bibr2-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000135226.53499.85"},{"key":"bibr3-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1246"},{"key":"bibr4-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1159\/000368814"},{"key":"bibr5-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf077"},{"key":"bibr6-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.986"},{"key":"bibr7-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.11.001"},{"key":"bibr8-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"bibr9-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70170-9"},{"key":"bibr10-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.023812"},{"key":"bibr11-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01923-X"},{"key":"bibr12-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1177\/2396987316663287"},{"key":"bibr13-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-266"},{"key":"bibr14-2048004020954628","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161228"},{"key":"bibr15-2048004020954628","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14563"},{"key":"bibr16-2048004020954628","unstructured":"Kenny RA, Whelan BJ, Cronin H, et\u00a0al. 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