{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:34:13Z","timestamp":1777545253807,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medline Co, Ltd","award":[": Bosentan (Unison Laboratories, Thailand) was do"],"award-info":[{"award-number":[": Bosentan (Unison Laboratories, Thailand) was do"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated the efficacy and safety of the bosentan as a sequential add-on therapy with sildenafil in pulmonary arterial hypertension with congenital heart disease (PAH-CHD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and method<\/jats:title>\n                    <jats:p>\n                      Twenty patients who were receiving sildenafil were given generic bosentan for up to a year. Hemodynamic data was collected from cardiac catheterization at pretreatment and at three months. Comparisons were made between the total scores of the four, low-risk criteria adapted from the 2015 ESC\/ERS pulmonary hypertension guidelines, which are: 1) WHO functional class of I or II, 2) 6MWD of more than 440\u2009m, 3) right atrial pressure of less than 8\u2009mm Hg, and 4) cardiac index \u22652.5\u2009L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      , performed at the beginning of therapy, 3-months, 6-months, and 1\u2009year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients\u2019 average age was 27\u2009\u00b1\u200911\u2009years old (12\u201353). PVRi decreased from 16.7\u2009\u00b1\u20099.5 to 12.7\u2009\u00b1\u200910.3 Wood unit (WU) m2 (p\u2009=\u20090.025) and PVRi\/SVRi decreased from 0.69\u2009\u00b1\u20090.33 to 0.49\u2009\u00b1\u20090.32 (p\u2009=\u20090.001). During the follow-up, the composite scoring of the low risk scores for 19 patients was increased significantly from 1.8\u2009\u00b1\u20091.0 at baseline to 2.3\u2009\u00b1\u20090.9 at 3\u2009months, to 2.9\u2009\u00b1\u20090.8 at 6\u2009months, and 3\u2009\u00b1\u20090.7 at 1\u2009year (p\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated intermediate term benefits for generic bosentan as an add-on therapy to sildenafil in patients with PAH-CHD by improving PVRi, and PVRi\/SVRi at three months. A significant improvement was also seen in the combined scores of the low-risk criteria from below 2 to 3 at one year (p\u2009=\u20090.001). Thai Clinical Trials Registry (TCTR): TCTR identification number is TCTR20200506006.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048004020982213","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T05:43:54Z","timestamp":1611207834000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved low-risk criteria scores for combination therapy of sildenafil and generic bosentan in patients with congenital heart disease with severe pulmonary hypertension: A prospective open label study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-516X","authenticated-orcid":false,"given":"Kritvikrom","family":"Durongpisitkul","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paweena","family":"Chungsomprasong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chodchanok","family":"Vijarnsorn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakul","family":"Chanthong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supaluck","family":"Kanjanauthai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarupim","family":"Soongswang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"bibr1-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02148-2018"},{"key":"bibr2-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"bibr3-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"bibr4-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.630715"},{"key":"bibr5-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02044-2014"},{"key":"bibr6-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033575"},{"key":"bibr7-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010075"},{"key":"bibr8-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"bibr9-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00889-2017"},{"key":"bibr10-2048004020982213","first-page":"421","volume":"94","author":"Durongpisitkul K","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"bibr11-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2016.1120672"},{"key":"bibr12-2048004020982213","first-page":"196","volume":"91","author":"Durongpisitkul K","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"bibr13-2048004020982213","first-page":"S60","volume":"88","author":"Durongpisitkul K","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"bibr14-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.61"},{"key":"bibr15-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9248-6"},{"key":"bibr16-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx257"},{"key":"bibr17-2048004020982213","first-page":"137","volume":"15","author":"Armamsareewong TJ","year":"2010","journal-title":"Thai Heart J"},{"key":"bibr18-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003912"},{"key":"bibr19-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.04.037"},{"key":"bibr20-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.04.078"},{"key":"bibr21-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.10.006"},{"key":"bibr22-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000060010.81321.45"},{"key":"bibr23-2048004020982213","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx301"}],"container-title":["JRSM Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2048004020982213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2048004020982213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2048004020982213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:32:46Z","timestamp":1777397566000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2048004020982213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":23,"alternative-id":["10.1177\/2048004020982213"],"URL":"https:\/\/doi.org\/10.1177\/2048004020982213","relation":{},"ISSN":["2048-0040","2048-0040"],"issn-type":[{"value":"2048-0040","type":"print"},{"value":"2048-0040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2048004020982213"}}