{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:34:33Z","timestamp":1777545273672,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Coagulation-fibrinolysis markers are widely used for the diagnosis of Stanford type A acute aortic dissection (SAAAD). However, the role of these markers in estimating prognosis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center retrospective study was conducted to identify the relationship between preoperative D-dimer and fibrinogen levels on SAAAD postoperative early prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 238 SAAAD patients who underwent surgery between January 2012 and December 2018, 201 (84.5%) and 37 (15.5%) patients constituted the survival and non-survival groups, respectively, 30 days after surgery. D-dimer and fibrinogen levels in the survival and non-survival groups were 45.2\u2009\u00b1\u200974.3 vs. 91.5\u2009\u00b1\u2009103.6\u2005\u03bcg\/mL ( p\u2009=\u20090.014) and 224.3\u2009\u00b1\u200995.6 vs. 179.9\u2009\u00b1\u200996.7 \u03bcg\/mL ( p\u2009=\u20090.012), respectively. According to logistic predictor analysis of 30-day mortality, significant factors showed patent type (OR 10.89, 95% CI 1.66\u201320.31) and malperfusion (OR 4.63, 95% CI 1.74\u201312.32). Increasing D-dimer (per +10\u2005\u03bcg\/mL) and decreasing fibrinogen (per \u221210\u2005\u03bcg\/mL) were significantly associated with patent type and malperfusion. Receiver operating characteristic analysis was performed to distinguish between survival and non-survival. The cutoff value of D-dimer was 60 \u03bcg\/mL (sensitivity 61.1%; specificity 82.5%; area under curve [AUC] 0.713\u2009\u00b1\u20090.083); fibrinogen was 150 mg\/dL (sensitivity 44.4%; specificity 84.0%; AUC 0.647\u2009\u00b1\u20090.092). Kaplan-Meier survival curve analysis showed that patients with D-dimer levels &gt; 60\u2005\u03bcg\/mL and fibrinogen levels &lt; 150\u2005mg\/dL had significantly low survival rates at 30 days after surgery (60.0%, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative coagulation-fibrinolysis markers may be useful for predicting early prognosis in SAAAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20480040211047122","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T06:31:50Z","timestamp":1637649110000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of coagulation-fibrinolysis markers for prognostication of Stanford type A acute aortic dissection"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-2895","authenticated-orcid":false,"given":"Daisuke","family":"Arima","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, 1187-299 Kaname, Tsukuba, Ibaraki 300-2622, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Suematsu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, 1187-299 Kaname, Tsukuba, Ibaraki 300-2622, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanan","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, 1187-299 Kaname, Tsukuba, Ibaraki 300-2622, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, 1187-299 Kaname, Tsukuba, Ibaraki 300-2622, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, 1187-299 Kaname, Tsukuba, Ibaraki 300-2622, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"bibr1-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000471"},{"key":"bibr2-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.833004"},{"key":"bibr3-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029457"},{"key":"bibr4-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000216686.72457.EC"},{"key":"bibr5-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2013.04.009"},{"key":"bibr6-20480040211047122","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3770"},{"key":"bibr7-20480040211047122","doi-asserted-by":"publisher","DOI":"10.7888\/juoeh.40.139"},{"key":"bibr8-20480040211047122","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.02.013"},{"key":"bibr9-20480040211047122","volume":"7","author":"Dong 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