{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:02:59Z","timestamp":1784635379695,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pacemakers (PMs) are crucial for treating symptomatic bradyarrhythmias and improving patient health-related quality of life (HRQoL). While Chagas disease (ChD) is known to impair HRQoL, its specific impact on PM recipients, as measured by the AQUAREL questionnaire, is not well understood. This study aimed to compare HRQoL between pacemaker patients with and without ChD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 57 adult patients with PM (29 with ChD and 28 without). HRQoL was evaluated using the AQUAREL questionnaire, which assesses three domains: Chest Discomfort, Arrhythmia, and Dyspnea. We used multivariate inflated beta regression models, adjusting for clinical and demographic covariates, to analyze the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with ChD (median age 64 years, interquartile range [IQR], 56\u201372 years) reported significantly worse HRQoL than those without ChD (median age 57 years, IQR, 53\u201369 years). After multivariate adjustment, ChD remained significantly associated with poorer HRQoL scores in all domains: Chest discomfort (adjusted odds ratio [OR] 0.59;\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      044), Arrhythmia (adj. OR 0.38;\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      004), and Dyspnea (adj. OR 0.61;\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      049). An OR\u2009&lt;\u20091 indicates worse outcomes for the ChD group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ChD is independently associated with a significantly poorer perception of HRQoL in pacemaker patients compared to those without ChD. This impairment spans the critical domains of chest discomfort, arrhythmia, and dyspnea, highlighting the distinct health burden imposed by ChD in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20480040261469407","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:31:12Z","timestamp":1784633472000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chagas disease and health-related quality of life in pacemaker patients: A cross-sectional analysis using the AQUAREL questionnaire"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7908-5557","authenticated-orcid":false,"given":"Victor Cordeiro","family":"Sim\u00e3o","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9549-1784","authenticated-orcid":false,"given":"Laura Porto","family":"Augusto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0132-3061","authenticated-orcid":false,"given":"Pedro Teixeira","family":"Guar\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6001-8265","authenticated-orcid":false,"given":"Luiz Ant\u00f4nio Batista","family":"De S\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s"},{"name":"Hospital das Cl\u00ednicas da Universidade Federal de Goi\u00e1s, Ambulat\u00f3rio de Marcapasso, Goi\u00e2nia, GO, 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