{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:20:22Z","timestamp":1786465222035,"version":"build-2736575974"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Cardiovascular Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrathin bioresorbable-polymer sirolimus-eluting stents (BP-SES), including bioresorbable scaffolds (BRS), were developed to mitigate adverse events associated with durable-polymer everolimus-eluting stents (DP-EES). This study aims to compare the efficacy and safety of BP-SES versus DP-EES in patients undergoing percutaneous coronary intervention for de novo coronary artery lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, ScienceDirect and ClinicalTrials.gov from inception to May 2026 for randomised controlled trials (RCTs) comparing BP-SES or BRS with DP-EES. Random-effects models were used to pool risk ratios (RRs) or mean differences with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen RCTs involving 18,501 patients were included. No significant differences were observed between BP-SES and DP-EES for target lesion failure (RR 1.15, 95% CI 0.74\u20131.79; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200994%), target vessel failure (RR 0.93, 95% CI 0.84\u20131.03; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200910%), cardiac death (RR 0.96, 95% CI 0.78\u20131.18), target vessel myocardial infarction (RR 0.89, 95% CI 0.77\u20131.03), clinically indicated target lesion revascularisation (RR 0.99, 95% CI 0.80\u20131.22). Binary restenosis was significantly higher in the BP-SES arm overall (RR 2.46, 95% CI 1.41\u20134.29;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Metallic BP-SES and DP-EES showed similar rates for most clinical endpoints. However, extreme heterogeneity and accrual of only 5.7% of the required information size render the evidence for target lesion failure inconclusive. Higher binary restenosis increased target lesion revascularisation with fully BRS indicate that these platforms are not interchangeable with contemporary metallic stents. Further large, long-term trials are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20480040261478165","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:54:54Z","timestamp":1786460094000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioresorbable-polymer sirolimus-eluting stents versus durable-polymer everolimus-eluting stents in percutaneous coronary intervention: A systematic review and meta-analysis of randomized controlled trials with GRADE assessment"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5021-4582","authenticated-orcid":false,"given":"Deepanshu","family":"Agrawat","sequence":"first","affiliation":[{"name":"Far Eastern Federal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1402-9026","authenticated-orcid":false,"given":"Aarushi","family":"Gupta","sequence":"additional","affiliation":[{"name":"DMC, Sinai Grace Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Rajpura","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8952-2765","authenticated-orcid":false,"given":"Sanaa Sadikhussain","family":"Diwan","sequence":"additional","affiliation":[{"name":"Ivane Javakhishvili Tbilisi State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2265-3798","authenticated-orcid":false,"given":"Mokshit Mehul","family":"Shah","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Azad Jammu and Kashmir Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umais Naveed","family":"Warraich","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areesha Talib","family":"Lashari","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usama","family":"Tariq","sequence":"additional","affiliation":[{"name":"Akhtar Saeed Medical and Dental College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Khan","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4048-0316","authenticated-orcid":false,"given":"Mirza Muhammad Hadeed","family":"Khawar","sequence":"additional","affiliation":[{"name":"Services Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7051-7413","authenticated-orcid":false,"given":"Muneeb","family":"Khawar","sequence":"additional","affiliation":[{"name":"King Edward Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28350"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae666.3630"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01812-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.725"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv203"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2011.00628.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0902-5"},{"key":"e_1_3_3_10_2","article-title":"Adverse cardiovascular events associated with biodegradable polymer drug-eluting stents and durable polymer everolimus-eluting stents: a systematic review and meta-analysis of 10 randomized controlled trials","volume":"96","author":"Bundhun PK","year":"2017","unstructured":"Bundhun PK, Janoo G, Yanamala CM, et al. Adverse cardiovascular events associated with biodegradable polymer drug-eluting stents and durable polymer everolimus-eluting stents: a systematic review and meta-analysis of 10 randomized controlled trials. Medicine 2017 Jul 1; 96: e7510.","journal-title":"Medicine"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2024.2375340"},{"key":"e_1_3_3_12_2","first-page":"243","article-title":"Bioresorbable vascular scaffold versus metallic drug-eluting stent in patients at high risk of restenosis: final 7-year results of the COMPARE-ABSORB trial","volume":"22","author":"Smits PC","year":"2026","unstructured":"Smits PC, W\u0142odarczak A, Chevalier B, et al. Bioresorbable vascular scaffold versus metallic drug-eluting stent in patients at high risk of restenosis: final 7-year results of the COMPARE-ABSORB trial. EuroInterv J EuroPCR Collaborat Working Group Interv Cardiol Eur Soc Cardiol 2026 Feb 1; 22: 243\u2013254.","journal-title":"EuroInterv J EuroPCR Collaborat Working Group Interv Cardiol Eur Soc Cardiol"},{"key":"e_1_3_3_13_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Br Med J 2021; 372: n71. PMID: 33782057.","journal-title":"Br Med J"},{"key":"e_1_3_3_14_2","article-title":"Rob 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JAC","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, et al. Rob 2: a revised tool for assessing risk of bias in randomised trials. Br Med J 2019; 366: l4898. PMID: 31462531.","journal-title":"Br Med J"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4097\/kja.21080"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-76"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00762"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54964-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.09.037"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02197-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.12.024"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2016.04.001"},{"key":"e_1_3_3_24_2","first-page":"1852","article-title":"Ultrathin bioresorbable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents: BIOFLOW V final 5-year outcomes","volume":"15","author":"Kandzari DE","year":"2022","unstructured":"Kandzari DE, Koolen JJ, Doros G, et al., BIOFLOW V Investigators. Ultrathin bioresorbable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents: BIOFLOW V final 5-year outcomes. Cardiovasc Interv 2022 Sep 26; 15: 1852\u20131860.","journal-title":"Cardiovasc Interv"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00409"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.04.014"},{"key":"e_1_3_3_27_2","first-page":"1020","article-title":"Randomized clinical trial of abluminus DES+ sirolimus-eluting stent versus everolimus-eluting DES for percutaneous coronary intervention in patients with diabetes mellitus: an optical coherence tomography study","volume":"102","author":"Maurina M","year":"2023","unstructured":"Maurina M, Chiarito M, Leone PP, et al. Randomized clinical trial of abluminus DES+ sirolimus-eluting stent versus everolimus-eluting DES for percutaneous coronary intervention in patients with diabetes mellitus: an optical coherence tomography study. Catheter Cardiovasc Interv 2023 Nov; 102: 1020\u20131033.","journal-title":"Catheter Cardiovasc Interv"},{"key":"e_1_3_3_28_2","first-page":"1324","article-title":"Ultrathin, biodegradable-polymer sirolimus-eluting stent vs thin, durable-polymer everolimus-eluting stent","volume":"15","author":"Nakamura M","year":"2022","unstructured":"Nakamura M, Kadota K, Nakagawa Y, et al. Ultrathin, biodegradable-polymer sirolimus-eluting stent vs thin, durable-polymer everolimus-eluting stent. Cardiovasc Interv 2022 Jul 11; 15: 1324\u20131334.","journal-title":"Cardiovasc Interv"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31715-X"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052482"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025765"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01214"},{"key":"e_1_3_3_33_2","first-page":"1450","article-title":"Thinner strut sirolimus-eluting BRS versus EES in patients with coronary artery disease: FUTURE-II trial","volume":"14","author":"Song L","year":"2021","unstructured":"Song L, Xu B, Chen Y, et al. Thinner strut sirolimus-eluting BRS versus EES in patients with coronary artery disease: FUTURE-II trial. Cardiovasc Interv 2021 Jul 12; 14: 1450\u20131462.","journal-title":"Cardiovasc Interv"},{"key":"e_1_3_3_34_2","article-title":"Final 3-year outcomes of mistent biodegradable polymer crystalline sirolimus-eluting stent versus xience permanent polymer everolimus-eluting stent: insights from the DESSOLVE III all-comers randomized trial","volume":"13","author":"Takahashi K","year":"2020","unstructured":"Takahashi K, Serruys PW, Kogame N, et al. Final 3-year outcomes of mistent biodegradable polymer crystalline sirolimus-eluting stent versus xience permanent polymer everolimus-eluting stent: insights from the DESSOLVE III all-comers randomized trial. Circ: Cardiovasc Interventions 2020 Jun; 13: e008737.","journal-title":"Circ: Cardiovasc Interventions"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.017"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00766"},{"key":"e_1_3_3_37_2","first-page":"1274","article-title":"Clinical outcomes with biodegradable polymer versus durable polymer drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis","volume":"383","author":"Palmerini T","year":"2014","unstructured":"Palmerini T, Biondi-Zoccai G, Della Riva D, et al. Clinical outcomes with biodegradable polymer versus durable polymer drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet 2014; 383: 1274\u20131283.","journal-title":"Lancet"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034456"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.003210"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_3_3_41_2","first-page":"1117","article-title":"Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer: pooled evidence from randomized trials","volume":"31","author":"Windecker S","year":"2010","unstructured":"Windecker S, Serruys PW, Wandel S, et al. Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer: pooled evidence from randomized trials. EurHeart J 2010; 31: 1117\u20131127.","journal-title":"EurHeart J"},{"key":"e_1_3_3_42_2","first-page":"1158","article-title":"Meta-analysis of randomized controlled trials comparing biodegradable polymer versus durable polymer drug-eluting stents","volume":"113","author":"El-Hayek G","year":"2014","unstructured":"El-Hayek G, Benjo A, Bangalore S, et al. Meta-analysis of randomized controlled trials comparing biodegradable polymer versus durable polymer drug-eluting stents. Am J Cardiol 2014; 113: 1158\u20131167.","journal-title":"Am J Cardiol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.07.040"},{"key":"e_1_3_3_44_2","first-page":"1607","article-title":"Long-term outcomes after biodegradable polymer sirolimus-eluting versus durable polymer everolimus-eluting stents","volume":"9","author":"Pilgrim T","year":"2016","unstructured":"Pilgrim T, Piccolo R, Heg D, et al. Long-term outcomes after biodegradable polymer sirolimus-eluting versus durable polymer everolimus-eluting stents. JACC Cardiovasc Interv 2016; 9: 1607\u20131615.","journal-title":"JACC Cardiovasc Interv"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6530"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_3_3_47_2","first-page":"3210","article-title":"Effect of ultrathin strut biodegradable polymer stents in small coronary vessels","volume":"33","author":"R\u00e4ber L","year":"2012","unstructured":"R\u00e4ber L, Kelb\u00e6k H, Ostojic M, et al. Effect of ultrathin strut biodegradable polymer stents in small coronary vessels. Eur Heart J 2012; 33: 3210\u20133219.","journal-title":"Eur Heart J"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957332"},{"key":"e_1_3_3_49_2","first-page":"1905","article-title":"1-year Outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease","volume":"373","author":"Stone GW","year":"2016","unstructured":"Stone GW, Gao R, Kimura T, et al. 1-year Outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease. N Engl J Med 2016; 373: 1905\u20131915.","journal-title":"N Engl J Med"},{"key":"e_1_3_3_50_2","first-page":"1321","article-title":"Three-year outcomes with the Absorb bioresorbable scaffold versus everolimus-eluting stents","volume":"394","author":"Ali ZA","year":"2019","unstructured":"Ali ZA, Gao R, Kimura T, et al. Three-year outcomes with the Absorb bioresorbable scaffold versus everolimus-eluting stents. Lancet 2019; 394: 1321\u20131331.","journal-title":"Lancet"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00979-4"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.017"},{"key":"e_1_3_3_53_2","first-page":"765","article-title":"Bioresorbable scaffolds: current evidence and future perspectives","volume":"36","author":"R\u00e4ber L","year":"2015","unstructured":"R\u00e4ber L, Onuma Y, Brugaletta S, et al. Bioresorbable scaffolds: current evidence and future perspectives. Eur Heart J 2015; 36: 765\u2013772.","journal-title":"Eur Heart J"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"}],"container-title":["JRSM Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20480040261478165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20480040261478165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20480040261478165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:55:19Z","timestamp":1786460119000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20480040261478165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":53,"alternative-id":["10.1177\/20480040261478165"],"URL":"https:\/\/doi.org\/10.1177\/20480040261478165","relation":{},"ISSN":["2048-0040","2048-0040"],"issn-type":[{"value":"2048-0040","type":"print"},{"value":"2048-0040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"20480040261478165"}}