{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:08:01Z","timestamp":1787393281473,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Heart Journal: Acute Cardiovascular Care"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The prevalence and outcome of patients with cancer that experience acute coronary syndrome (ACS) have to be determined. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results:<\/jats:title><jats:p> The BleeMACS project is a multicentre observational registry enrolling patients with acute coronary syndrome undergoing percutaneous coronary intervention worldwide in 15 hospitals. The primary endpoint was a composite event of death and re-infarction after one year of follow-up. Bleedings were the secondary endpoint. 15,401 patients were enrolled, 926 (6.4%) in the cancer group and 14,475 (93.6%) in the group of patients without cancer. Patients with cancer were older (70.8\u00b110.3 vs. 62.8\u00b112.1 years, P&lt;0.001) with more severe comorbidities and presented more frequently with non-ST-segment elevation myocardial infarction compared with patients without cancer. After one year, patients with cancer more often experienced the composite endpoint (15.2% vs. 5.3%, P&lt;0.001) and bleedings (6.5% vs. 3%, P&lt;0.001). At multiple regression analysis the presence of cancer was the strongest independent predictor for the primary endpoint (hazard ratio (HR) 2.1, 1.8\u20132.5, P&lt;0.001) and bleedings (HR 1.5, 1.1\u20132.1, P=0.015). Despite patients with cancer generally being undertreated, beta-blockers (relative risk (RR) 0.6, 0.4\u20130.9, P=0.05), angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers (RR 0.5, 0.3\u20130.8, P=0.02), statins (RR 0.3, 0.2\u20130.5, P&lt;0.001) and dual antiplatelet therapy (RR 0.5, 0.3\u20130.9, P=0.05) were shown to be protective factors, while proton pump inhibitors (RR 1, 0.6\u20131.5, P=0.9) were neutral. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Cancer has a non-negligible prevalence in patients with acute coronary syndrome undergoing percutaneous coronary intervention, with a major risk of cardiovascular events and bleedings. Moreover, these patients are often undertreated from clinical despite medical therapy seems to be protective. Registration:The BleeMACS project (NCT02466854). <\/jats:p><\/jats:sec>","DOI":"10.1177\/2048872617706501","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T09:44:21Z","timestamp":1496915061000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Prevalence and outcome of patients with cancer and acute coronary syndrome undergoing percutaneous coronary intervention: a BleeMACS substudy"],"prefix":"10.1093","volume":"7","author":[{"given":"Mario","family":"Iannaccone","sequence":"first","affiliation":[{"name":"San Giovanni Bosco Hospital, Turin, Italy"},{"name":"Dipartimento di Scienze Mediche, Citt\u00e0 della Salute e della Scienza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Citt\u00e0 della Salute e della 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