{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:31:43Z","timestamp":1763037103241},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Heart Journal: Acute Cardiovascular Care"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> We sought to evaluate the impact of prior cerebrovascular and\/or peripheral arterial disease (PAD) on in-hospital outcomes in patients with acute coronary syndromes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> From 1 October 2010 to 26 February 2016, 13,904 acute coronary syndrome patients were enrolled in a national multicentre registry. They were divided into four groups: prior stroke\/transient ischaemic attack (stroke\/TIA); prior PAD; prior stroke\/TIA and PAD; none. The endpoints included in-hospital mortality and a composite endpoint of death, re-infarction and stroke during hospitalization. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> 6.3% patients had prior stroke\/TIA, 4.2% prior PAD and 1.4% prior stroke\/TIA and PAD. Prior stroke\/TIA and\/or PAD patients were less likely to receive evidence-based medical therapies (dual antiplatelet therapy: stroke\/TIA= 88.6%, PAD= 86.6%, stroke\/TIA+PAD= 85.7%, none= 92.2%, p&lt;0.001; \u03b2-blockers: stroke\/TIA= 77.1%, PAD= 72.1%, stroke\/TIA+PAD= 71.9%, none= 80.8%, p&lt;0.001; angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers: stroke\/TIA= 86.3%, PAD= 83.6%, stroke\/TIA+PAD= 83.2%, none= 87.1%, p=0.030) and to undergo percutaneous revascularization (stroke\/TIA= 52.8%, PAD= 45.6%, stroke\/TIA+PAD= 43.7%, none= 67.9%, p&lt;0.001), despite more extensive coronary artery disease (three-vessel disease: stroke\/TIA= 29.1%, PAD= 38.3%, stroke\/TIA+PAD= 38.3%, none= 20.2%, p&lt;0.001). In a multivariable analysis, prior stroke\/TIA+PAD was a predictor of in-hospital mortality (odds ratio= 2.828, 95% confidence interval 1.001\u20137.990) and prior stroke\/TIA (odds ratio= 1.529, 95% confidence interval 1.056\u20132.211), prior PAD (odds ratio= 1.618, 95% confidence interval 1.034\u20132.533) and both conditions (odds ratio= 3.736, 95% confidence interval 2.002\u20136.974) were associated with the composite endpoint. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> A prior history of stroke\/TIA and\/or PAD was associated with lower use of medical therapy and coronary revascularization and with worst short-term prognosis. An individualized management may improve their poor prognosis. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2048872617716388","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T14:04:58Z","timestamp":1497881098000},"page":"652-660","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Short-term prognostic effect of prior cerebrovascular and peripheral artery disease in patients with acute coronary syndrome: Can we do better?"],"prefix":"10.1093","volume":"7","author":[{"given":"Filipa","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro S","family":"Mateus","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Leao","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Moz","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Ilidio","family":"Moreira","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tras-os-Montes e Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the 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